(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

Zanos, Panos; Highland, Jaclyn N.; Liu, Xin; Troppoli, Timothy A.; Georgiou, Polymnia; Lovett, Jacqueline; Morris, Patrick J.; Stewart, Brent W.; Thomas, Craig J.; Thompson, Scott M.; Moaddel, Ruin; Gould, Todd D.

doi:10.1111/bph.14683

(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

Background and Purpose ( R )‐Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While ( R )‐ketamine has lower potency than ( R,S )‐ketamine to inhibit NMDA receptors in vitro, the extent to which ( R )‐ketamine shares the NMDA receptor‐mediated adverse effects of ( R,S )‐…