Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases
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Items 101–200 of 321
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- Cellular senescence signaling in cancer: A novel therapeutic target to combat human malignanciesSajad Fakhri, Seyed Zachariah Moradi, Lindsay K. DeLiberto, Anupam Bishayee · 2022 · Biochemical Pharmacology
- The Molecular Intersection Between Senescence and Major Depression in the ElderlyBreno Satler Diniz · 2018 · American Journal of Geriatric Psychiatry
- Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activationPreininger, Marcela K., Zaytseva, Dasha, Lin, Jessica May, Kaufer, Daniela · 2023 · Aging Cell
- Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes MellitusJulia Carracedo, Matilde Alique, Rafael Ramírez-Carracedo, Guillermo Bodega, Rafael Ramı́rez · 2018 · Current Vascular Pharmacology
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- Role of Low‐Density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus ErythematosusHua‐Chen Chan, Hsiu‐Chuan Chan, Chan‐Jung Liang, Hsiang‐Chun Lee, Hung Su, An‐Sheng Lee, Jentaie Shiea, Wen‐Chan Tsai, Tsan‐Teng Ou, Cheng‐Chin Wu et al. · 2020 · Arthritis & Rheumatology
- BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human DiseaseGaoyu Zu, Ying Liu, Jingli Cao, Baicheng Zhao, Hang Zhang, Linya You · 2022 · Cancers
- ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytesSven Eric Niklander, Deepti Bandaru, D Lambert, Keith David Hunter · 2020 · FEBS Open Bio
- Cellular senescence in gliomaRafał Chojak, Jawad Fares, Edgar Petrosyan, Maciej S. Lesniak · 2023 · Journal of Neuro-Oncology
- Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cellsTamio Okimoto, Hitoshi Kotani, Yuichi Iida, Akira Koyanagi, Ryosuke Tanino, Yukari Tsubata, Takeshi Isobe, Mamoru Harada · 2020 · Cancer Science
- Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and RejuvenationEkaterina M. Samoilova, Белопасов Владимир Викторович, Evgenia V. Ekusheva, Chao Zhang, A. V. Troitskiy, Vladimir P. Baklaushev · 2021 · Journal of Personalized Medicine
- An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescenceMarie Saitou, Darleny Y. Lizardo, Recep Özgür Taşkent, Alec Millner, Ömer Gökçümen, Gunes Ekin Atilla‐Gokcumen · 2018 · Molecular Omics
- Cytokine and Chemokine Concentration in the Tear of Patients with Age-Related CataractCarolina Engelbrecht, Luiz Roberto Sardinha, Luiz Vicente Rizzo · 2020 · Current Eye Research
- Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasiaSharon A. McGrath‐Morrow, Roland Ndeh, Joseph Michael Collaco, Cynthia Rothblum‐Oviatt, Jennifer Wright, Michael A. O’Reilly, Benjamin David Singer, Howard M. Lederman · 2018 · PLoS ONE
- Beta Cell Therapies for Preventing Type 1 Diabetes: From Bench to BedsideGabriel M. Brawerman, Peter J. Thompson · 2020 · Biomolecules
- Reliable Hallmarks and Biomarkers of Senescent LymphocytesМартышкина Юлия Сергеевна, Valeriy Tereshchenko, Daria A. Bogdanova, Рыбцов Станислав Александрович · 2023 · International Journal of Molecular Sciences
- Xiyangshen Sanqi Danshen granules attenuated D-gal-induced C57BL/6J mouse aging through the AMPK/SIRT1 signaling pathwayZhiru Yin, Liangliang Tian, Wenzhuo Kou, Guangzhao Cao, Li‐Ju Wang, Yu-Fa Xia, Yidong Lin, Shihuan Tang, Jingjing Zhang, Hongjun Yang · 2024 · Phytomedicine
- Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligaseSivareddy Kotla, Nhat‐Tu Le, Hang Thi Vu, Kyung Ae Ko, Young Jin Gi, Tamlyn N. Thomas, Carolyn J. Giancursio, Aldos J. Lusis, John P. Cooke, Keigi Fujiwara et al. · 2019 · Metabolism
- Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cellsJosiane Weber Tessmann, Murilo Ramos Rocha, José Andrés Morgado‐Díaz · 2022 · Journal of Cellular Biochemistry
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- Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertensionKai Li, Yan Li, Youjia Yu, Jingjing Ding, Huijie Huang, Chunyan Chu, Li Hu, Yanfang Yu, Yue Zhou Cao, Peng Xu et al. · 2021 · BMC Pulmonary Medicine
- Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling PatternsHira Hasan, Sin‐Hee Park, Cyril Auger, Eugenia Belcastro, Kensuke Matsushita, Benjamin Marchandot, Hyun-Ho Lee, Abdul Wahid Qureshi, Gilles Kauffenstein, Patrick Ohlmann et al. · 2019 · Journal of Clinical Medicine
- Mitochondria and chronic effects of cancer therapeutics: The clinical implicationsAbishai Dominic, Dale J. Hamilton, Jun‐ichi Abe · 2020 · Journal of Thrombosis and Thrombolysis
- IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2Yuki Nakamura, Riho Aihara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna · 2020 · American Journal of Reproductive Immunology
- Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPDHirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro, Junji Yodoi · 2021 · Antioxidants
- Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cellsKazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara · 2022 · Toxicology and Applied Pharmacology
- The role of Sirtuin 1 and its activators in age-related lung diseaseChaoqun Sun, Shuyou Bai, Yanmei Liang, Dewei Liu, Jinyu Liao, Yujuan Chen, Xuanna Zhao, Bin Wu, Dan Huang, Min Chen et al. · 2023 · Biomedicine & Pharmacotherapy
- Pathogenesis of Warthin’s Tumor: Neoplastic or Non-Neoplastic?Ryogo Aoki, Takuji Tanaka · 2024 · Cancers
- Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progressionDu Hyun Ro, Gun Hee Cho, Ji Yoon Kim, Seongki Min, Ha Ru Yang, Hee Jung Park, Sun Young Wang, You Jung Kim, Myung Chul Lee, Hyun Cheol Bae et al. · 2024 · Aging Cell
- Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial FunctionsParveen Bazard, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu et al. · 2021 · Cells
- Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney FibrosisLi Shen, Song Jiang, Qingyan Zhang, Bo Ram Jin, Daoyuan Lv, Wenju Li, Min Zhao, Chunming Jiang, Chunsun Dai, Zhihong Liu · 2021 · Frontiers in Cell and Developmental Biology
- Senescence and senolysis in cancer: The latest findingsYoshimi Imawari, Makoto Nakanishi · 2024 · Cancer Science
- Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell TransplantationRichard Jirui Lin, Harold Kunal Elias, Marcel R.M. van den Brink · 2021 · Frontiers in Immunology
- Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in miceYoshiki Hirata, Yusuke Katsukura, Yuka Henmi, Ren Ozawa, Sayaka Shimazaki, Akira Kurosawa, Yasushi Torii, Hironori Takahashi, Hisataka Iwata, Takehito Kuwayama et al. · 2021 · Journal of Reproduction and Development
- Mesenchymal Stem Cell Senescence and OsteogenesisArtaria Tjempakasari, Heri Suroto, Djoko Santoso · 2021 · Medicina
- Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain AgingElena D. Osipova, Yulia K. Komleva, Andrey V. Morgun, Olga L. Lopatina, Yu. A. Panina, Raissa Ya. Olovyannikova, E. F. Vais, Vladimir V. Salmin, Alla B. Salmina · 2018 · Frontiers in Aging Neuroscience
- YBX1: A Multifunctional Protein in Senescence and Immune RegulationWenze Zhang, Ying Liu, Zhe Zhao, Yizhi Zhang, Yujuan Liang, Wanxia Wang · 2024 · Current Issues in Molecular Biology
- Regulatory Roles of Bone in Neurodegenerative DiseasesZhengran Yu, Zemin Ling, Lu Lin, Jin Xia Zhao, Xiang Chen, Pingyi Xu, Xuenong Zou · 2020 · Frontiers in Aging Neuroscience
- ING Proteins: Tumour Suppressors or OncoproteinsKarine Jacquet, Olivier Binda · 2021 · Cancers
- Analysis of senescence in gingival tissues and gingival fibroblast culturesMasae Furukawa, Kazunari Matsuda, Yu Aoki, Mitsuyoshi Yamada, Jingshu Wang, MAKI WATANABE, Mie Kurosawa, Yosuke Shikama, Kenji Matsushita · 2022 · Clinical and Experimental Dental Research
- Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancerX.F. Steven Zheng, Zefu Liu, Jianliang Zhong, Liwen Zhou, Jiawei Chen, Lisi Zheng, Zhiyong Li, Ruhua Zhang, Jingxuan Pan, Yuanzhong Wu et al. · 2022 · Oncogene
- Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin agingKento Takaya, Toru Asou, Kazuo Kishi · 2022 · GeroScience
- Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expressionPriscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto · 2022 · Frontiers in Medicine
- Targeting the epigenetic reader “BET” as a therapeutic strategy for cancerAbhishek Wahi, Namish Manchanda, Priti Jain, Hemant R. Jadhav · 2023 · Bioorganic Chemistry
- Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cellsKotomi Seno, Nao Tanikawa, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna · 2018 · American Journal of Reproductive Immunology
- Organismal Aging and Oxidants beyond Macromolecules DamageMarie‐Véronique Clement, Le Luo · 2019 · PROTEOMICS
- Dedifferentiation and in vivo reprogramming of committed cells in wound repair (Review)Yanjie Guo, Weini Wu, Xueyi Yang, Xiaobing Fu · 2022 · Molecular Medicine Reports
- Artificial Intelligence–Derived Electrocardiogram Assessment of Cardiac Age and Molecular Markers of Senescence in Heart FailureDhivya Vadhana Meenakshi Siddharthan, Christopher Livia, Timothy E. Peterson, Paul G. Stalboerger, Zachi Itzhak Attia, Alfredo L. Clavell, Paul A. Friedman, Suraj Kapa, Peter A. Noseworthy, Marissa J. Schafer et al. · 2023 · Mayo Clinic Proceedings
- Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular DiseasesMengjuan Lin, Shi-Liang Hu, Ying Tian, Zhang Jing, Na Liang, Rong Sun, Shao-Xin Gong, Aiping Wang · 2023 · Journal of Cardiovascular Translational Research
- A dynamical systems model for the measurement of cellular senescenceDaniel Galvis, Darren A. Walsh, Lorna W. Harries, Eva Latorre, James Rankin · 2019 · Journal of The Royal Society Interface
- A multi‐omics study to monitor senescence‐associated secretory phenotypes of Alzheimer's diseaseJingzhi Yang, Yinge Zhou, Tianjiao Wang, Na Li, Yufan Chao, Songyan Gao, Qun Zhang, Shuo Wu, Liang Zhao, Xin Wen Dong · 2024 · Annals of Clinical and Translational Neurology
- Christensenella minuta protects and restores intestinal barrier in a colitis mouse model by regulating inflammationCamille Kropp, Kevin Tambosco, Sead Chadi, Philippe Langella, Sandrine P. Claus, Rebeca Martín · 2024 · npj Biofilms and Microbiomes
- Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitroJiarui Li, Lei Xian, Ruipeng Zheng, Yue Wang, Xiaoqiang Wan, Ying Liu · 2022 · International Immunopharmacology
- Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar ratsVerónica Salas-Venegas, Roberto Santín-Márquez, Ricardo Jair Ramírez Carreto, Yesica María Rodríguez-Cortés, Agustina Cano-Martı́nez, Armando Luna‐López, Anahí Chavarría, Mina Königsberg, Norma Edith López‐Díazguerrero · 2023 · Frontiers in Aging Neuroscience
- Key Molecular Mechanisms of Aging, Biomarkers, and Potential InterventionsEkaterina Proshkina, Ilya A. Solovev, Mikhail Vyacheslavovich Shaposhnikov, Alexey Moskalev · 2020 · Molecular Biology
- MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong LifespanMingfu Tian, Yuqing Huang, Yunting Song, Wen Li, Peiyi Zhao, Weiyong Liu, Kailang Wu, Jianguo Wu · 2020 · Advanced Science
- Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolutionAtefeh Taherian Fard, Hannah C. Leeson, Julio Aguado, Giovanni Pietrogrande, Dominique Power, Cecilia Gómez‐Inclán, Huiwen Zheng, Christopher B. Nelson, Mohammad Soheilmoghaddam, Nick R. Glass et al. · 2023 · GeroScience
- Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeuticsSamsul Arefin, Neja Mudrovcic, Sam Hobson, Federico Pietrocola, Thomas Ebert, Liam J. Ward, Anna Witasp, Leah N. Hernandez, Lars M. Wennberg, Torbjörn Lundgren et al. · 2024 · Translational research
- In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressorsRohit Sharma, Yogendra Shantaram Padwad · 2019 · Nutrition
- Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problemJacob M. Smigiel, Sarah E. Taylor, Benjamin L. Bryson, Ilaria Tamagno, Kelsey L. Polak, Mark W. Jackson · 2019 · Journal of Cancer Metastasis and Treatment
- P16INK4a played a critical role in exacerbating acute tubular necrosis in acute kidney injury.Xin Gu, Chengyi Peng, Shiyu Lin, Ziyue Qin, Jialong Liang, Hongjie Chen, Chen-xing Hou, Rong Wang, Yingqiang Du, Jianliang Jin et al. · 2019 · PubMed Central
- Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cellsAmy Huei‐Yi Lee, Deepraj Ghosh, Ivy L. Koh, Michelle Dawson · 2023 · Aging
- Cellular senescence and liver disease: Mechanisms and therapeutic strategiesMei Guo · 2017 · Biomedicine & Pharmacotherapy
- Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенцииEkaterina Proshkina, И. А. Соловьёв, Mikhail Vyacheslavovich Shaposhnikov, A.A. Moskalev · 2020 · Molecular Biology
- The Potential Role of Senescence As a Modulator of Platelets and TumorigenesisClaudio A. Valenzuela, Ricardo Quintanilla, Rodrigo Moore‐Carrasco, Nelson E. Brown · 2017 · Frontiers in Oncology
- DNA demethylation with 5-aza-2′-deoxycytidine induces the senescence-associated secretory phenotype in the immortal fish cell line, EPCKunihiko Futami, Masashi Maita, Takayuki Katagiri · 2019 · Gene
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- Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?Sajad Alavimanesh, Negar Nayerain Jazi, Maedeh Choubani, Farzane Saeidi, Hamed Afkhami, Aref Yarahmadi, Hossein Ronaghi, Pouria Khani, Mohammad Hossein Modarressi · 2025 · Clinical and Experimental Medicine
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- Cellular Senescence and Anti-Cancer TherapyJieqiong You, Rong Dong, Meidan Ying, Qiaojun He, Ji Cao, Bo Yang · 2018 · Current Drug Targets
- Stem Cell-Derived Extracellular Vesicles in Skin Antiaging TreatmentsJi Yeong Park, Se Young Jung, Donghyeon Yoo, Sihun Lee, Dabin Go, Van Dat Bui, Won‐Kyo Jung, Dong Gil You, Jae Hyung Park, Wooram Um · 2025 · ACS Nano
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- Autophagy-dependent splicing control directs translation toward inflammation during senescenceJae‐Jin Kim, Yeonghyeon Lee, Taerang Jeon, Seonmin Ju, Jong‐Seo Kim, Mi-Sung Kim, Chanhee Kang · 2024 · Developmental Cell
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- Alteration of Hypoxia-Associated Gene Expression in Replicatively Senescent Mesenchymal Stromal Cells under Physiological Oxygen LevelAndrey Yu. Ratushnyy, Yu. V. Rudimova, Ludmila B. Buravkova · 2019 · Biochemistry (Moscow)
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