Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy

Inhibition of immune checkpoint molecules, PD ‐1 and CTLA 4, has been shown to be a promising cancer treatment. PD ‐1 and CTLA 4 inhibit TCR and co‐stimulatory signals. The third T cell activation signal represents the signals from the cytokine receptors. The cytokine interferon‐γ ( IFN γ) plays …