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Cited by 62Asthma and respiratory diseasesChild and Adolescent Psychosocial and Emotional DevelopmentDermatology and Skin Diseases

The familial aggregation of atopic diseases and depression or anxiety in children

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Brew, B. K., Lundholm, C., Gong, T., Larsson, H., Almqvist, C.·2018·Clinical & Experimental Allergy
DOI 10.1111/cea.13127PMC PMC6001531
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Abstract

Summary: Background: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases has strong genetic and environmental components; therefore, it seems likely that there is a shared liability rather than causative risk. Objective: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety. Methods: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n = 14 197. Current and ever asthma, eczema, hay fever and food allergy were reported by parents. Internalizing disorders were identified using validated questionnaires. Familial co‐aggregation analysis compared monozygotic (MZ) twins and same‐sex dizygotic (DZ) twins for atopic disease in 1 twin with internalizing disorder in the other to test for genetic liability. Several familial liability candidates were also tested including parental education, recent maternal psychological stress, childhood family trauma and parental country of birth. Results: Familial co‐aggregation analysis found that if 1 twin had at least 1 current atopic disease the partner twin was at risk of having an internalizing disorder regardless of their own atopic status (adjusted OR 1.22 (95% CI 1.08, 1.37). Similar results were found for each atopic disease ever and current. MZ associations were not higher than DZ associations, suggesting that the liability is not genetic in nature. Including other familial candidates to the models made little difference to effect estimates. Conclusions and Clinical Relevance: Atopic diseases and depression or anxiety tend to occur together in families; therefore, when treating for 1 disease, the physician should consider comorbidity in both the individual and the individual's siblings. We did not find evidence to support a genetic explanation for comorbidity, and further exploration is needed to disentangle the environmental and epigenetic reasons for familial aggregation.

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  • Some features of asthma overlap with symptoms of anxiety, and the association between asthma and anxiety has been reported extensively in the scientific literature.

    “Some of the features of asthma overlap with symptoms of anxiety and the association between asthma and anxiety has been reported extensively in the scientific literature (Brew, Lundholm, Gong, Larsson & Almqvist, 2018;Brew, Lundholm, Viktorin, Lichtenstein, Larsson & Almqvist, 2018;Ciprandi, Schiavetti, Rindone & Ricciardolo, 2015).”

    From Exposure‐based cognitive behavior therapy for anxiety related to asthma: A feasibility study with multivariate baseline design. (2020) · cites this paper as Brew, Lundholm, Gong, Larsson & Almqvist, 2018

    The Introduction says asthma and anxiety disorders have long been associated, and the Discussion reports an asthma–depression or anxiety association in children that is comparable with other studies. The cited paper does not say that features of asthma overlap with symptoms of anxiety; searches for symptom overlap found no supporting passage. Page numbers were not available in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 37

  1. [1]Katon W, Richardson L, Lozano P, McCauley E. The relationship of asthma and anxiety disorders. Psychosom Med. 2004; 66: 349‐ 355. 15184694
  2. [2]Blackman J, Gurka M. Developmental and behavioural comorbidities of asthma in children. J Dev Behav Pediatr. 2007; 28: 92‐ 99. 17435459
  3. [4]Shanahan L, Zucker N, Copeland WE, Costello EJ, Angold A. Are children and adolescents with food allergies at increased risk for psychopathology? J Psychosom Res. 2014; 77: 468‐ 473. 25454290 PMC4307934
  4. [5]Yaghmaie P, Koudelka CW, Simpson EL. Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol. 2013; 131: 428‐ 433. 23245818 PMC3565469
  5. [6]Audino P, La Grutta S, Cibella F, et al. Rhinitis as a risk factor for depressive mood in pre‐adolescents: a new approach to this relationship. Pediatr Allergy Immunol. 2014; 25: 360‐ 365. 24628692
  6. [7]Chida Y, Hamer M, Steptoe A. A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta‐analysis. Psychosom Med. 2008; 70: 102‐ 116. 18158379
  7. [8]Hasler G, Gergen PJ, Kleinbaum DG, et al. Asthma and panic in young adults: a 20‐year prospective community study. Am J Respir Crit Care Med. 2005; 171: 1224‐ 1230. 15764721 PMC2718460
  8. [9]Wamboldt MZ, Hewitt J, Schmitz S, et al. Familial assocation between allergic disorders and depression in adult Finnish twins. Am J Med Genet. 2000; 96: 146‐ 153. 10893486
  9. [10]Ullemar V, Magnusson PK, Lundholm C, et al. Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy. 2016; 71: 230‐ 238. 26786172
  10. [11]Boomsma DI, van Beijsterveldt CEM, Hudziak JJ. Genetic and environmental influences on Anxious/Depression during childhood: a study from the Netherlands Twin Register. Genes Brain Behav. 2005; 4: 466‐ 481. 16268991
  11. [12]Andersson NW, Hansen MV, Larsen AD, Hougaard KS, Kolstad HA, Schlunssen V. Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies. Allergy. 2016; 71: 15‐ 26. 26395995 PMC5054838
  12. [13]Polloni L, Ferruzza E, Ronconi L, et al. Perinatal stress and food allergy: a preliminary study on maternal reports. Psychol Health Med. 2015; 20: 732‐ 741. 25531062
  13. [15]Uphoff E, Cabieses B, Pinart M, Valdes M, Anto JM, Wright J. A systematic review of socioeconomic position in relation to asthma and allergic diseases. Eur Respir J. 2015; 46: 364‐ 374. 25537562
  14. [17]Richardson R, Westley T, Gariepy G, Austin N, Nandi A. Neighborhood socioeconomic conditions and depression: a systematic review and meta‐analysis. Soc Psychiatry Psychiatr Epidemiol. 2015; 50: 1641‐ 1656. 26164028
  15. [18]Magnusson PK, Almqvist C, Rahman I, et al. The Swedish Twin Registry: establishment of a biobank and other recent developments. Twin Res Hum Genet. 2013; 16: 317‐ 329. 23137839
  16. [19]Anckarsater H, Lundstrom S, Kollberg L, et al. The Child and Adolescent Twin Study in Sweden (CATSS). Twin Res Hum Gen. 2012; 14: 495‐ 508. 22506305
  17. [20]Ludvigsson JF, Almqvist C, Bonamy AE, et al. Registers of the Swedish total population and their use in medical research. Eur J Epidemiol. 2016; 31: 125‐ 136. 26769609
  18. [21]Birmaher B, Brent D, Chiapetta L, Bridge J, Monga S, Baugher M. Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a Replication Study. J Am Acad Child Adolesc Psychiatry. 1999; 38: 1230‐ 1236. 10517055
  19. [23]Angold A, Erkanli A, Silberg J, Eaves LJ, Costello EJ. Depression scale scores in 8‐17 year olds: effects of age and gender. J Child Psychol Psychiatry. 2002; 43: 1052‐ 1063. 12455926
  20. [25]Wolfe JW, Kimerling R, Brown PJ, Chrestman K, Levin K. Psychometric review of the Life Stressor Checklist‐Revised In: Stamm H, ed. Measurement of Stress, Trauma and Adaptation. Lutherville, MD: Sidran Press; 1996: 198‐ 201.
  21. [26]Yao S, Kuja‐Halkola R, Thornton LM, et al. Familial liability for eating disorders and suicide attempts: evidence from a population registry in Sweden. JAMA Psychiatry. 2016; 73: 284‐ 291. 26764185
  22. [27]Ortqvist AK, Lundholm C, Wettermark B, Ludvigsson JF, Ye W, Almqvist C. Validation of asthma and eczema in population‐based Swedish drug and patient registers. Pharmacoepidemiol Drug Saf. 2013; 22: 850‐ 860. 23754713
  23. [28]Collins JE, Gill TK, Chittleborough CR, Martin AJ, Taylor AW, Winefield H. Mental, emotional, and social problems among school children with asthma. J Asthma. 2008; 45: 489‐ 493. 18612902
  24. [29]Feitosa CA, Santos DN, Barreto do Carmo MB, et al. Behavior problems and prevalence of asthma symptoms among Brazilian children. J Psychosom Res. 2011; 71: 160‐ 165. 21843751 PMC3160547
  25. [30]Lee S, Shin A. Association of atopic dermatitis with depressive symptoms and suicidal behaviors among adolescents in Korea: the 2013 Korean Youth Risk Behavior Survey. BMC Psychiatry. 2017; 17: 3. 28049449 PMC5209888
  26. [31]Polloni L, Ferruzza E, Ronconi L, et al. Mental health and behavior of food‐allergic adolescents compared to a healthy matched sample. Ann Allergy Asthma Immunol. 2015; 115: 158‐ 160. 26250773
  27. [34]Slattery MJ, Essex MJ, Paletz EM, et al. Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis. J Allergy Clin Immunol. 2011; 128: 668‐ 671. 21684588 PMC3164894
  28. [35]Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy. 2010; 65: 933‐ 945. 20180792
  29. [36]Lee A, Mathilda Chiu YH, Rosa MJ, et al. Prenatal and postnatal stress and asthma in children: Temporal‐ and sexspecific associations. J Allergy Clin Immunol. 2016; 138: 740‐ 747. 26953156 PMC5011027
  30. [37]Liu X, Olsen J, Agerbo E, et al. Psychological stress and hospitalization for childhood asthma‐a nationwide cohort study in two Nordic countries. PLoS One. 2013; 8: e78816. 24205324 PMC3808299
  31. [38]Medsker BH, Brew BK, Forno E, et al. Maternal depressive symptoms, maternal asthma, and asthma in schoolaged children. Ann Allergy Asthma Immunol. 2017; 118: 55‐ 60. 28007088 PMC5189715
  32. [39]van de Loo KF, van Gelder MM, Roukema J, Roeleveld N, Merkus PJ, Verhaak CM. Prenatal maternal psychological stress and childhood asthma and wheezing: a meta‐analysis. Eur Respir J. 2016; 47: 133‐ 146. 26541526
  33. [40]Wright RJ, Finn P, Contreras JP, et al. Chronic caregiver stress and IgE expression, allergen‐induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy. J Allergy Clin Immunol. 2004; 113: 1051‐ 1057. 15208584
  34. [41]Chen E, Chim LS, Strunk RC, Miller GE. The role of the social environment in children and adolescents with asthma. Am J Respir Crit Care Med. 2007; 176: 644‐ 649. 17556714 PMC1994239
  35. [42]Miller GE, Gaudin A, Zysk E, Chen E. Parental support and cytokine activity in childhood asthma: the role of glucocorticoid sensitivity. J Allergy Clin Immunol. 2009; 123: 824‐ 830. 19181373
  36. [43]Lim J, Wood BL, Miller BD. Maternal depression and parenting in relation to child internalizing symptoms and asthma disease activity. J Fam Psychol. 2008; 22: 264‐ 273. 18410213
  37. [45]Ullemar V, Lundholm C, Almqvist C. Twins’ risk of childhood asthma mediated by gestational age and birthweight. Clin Exp Allergy. 2015; 45: 1328‐ 1336. 25845700

Cited by

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Authors
Brew, B. K., Lundholm, C., Gong, T., Larsson, H., & Almqvist, C.
Affiliations
  • Karolinska Institutet (SE)
  • The University of Sydney (AU)
  • Örebro University (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Brew, B. K.
ORCID
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
2018-04
Volume
48
Issue
6
Pages
703-711
ISSN
  • 0954-7894 (ISSN-L)
  • 1365-2222
DOI
10.1111/cea.13127
PMC
PMC6001531
OpenAlex
W2791861146
Cited by
62
References
8
Citations by year
2025: 8 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 2
FWCI
6.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical & Experimental Allergy (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders
  • Vetenskapsrådet (340‐2013‐5867)
  • Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2015‐00289)
  • Stockholms Läns Landsting
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
atopic diseases, asthma, atopic dermatitis, allergic rhinitis, food allergy, depression, anxiety, internalizing disorders, familial aggregation, comorbidities, monozygotic twins, dizygotic twins, genetic susceptibility, parental education, maternal stress, parental country of birth
MeSH terms
Anxiety, Child, Cross-Sectional Studies, Depression, Female, Humans, Hypersensitivity, Immediate, Male, Risk Factors, Sweden, Odds Ratio, Risk Assessment, Public Health Surveillance

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