High Concentration Hydrogen Protects Sepsis‐Associated Encephalopathy by Enhancing Pink1/Parkin‐Mediated Mitophagy and Inhibiting cGAS ‐ STING ‐ IRF3 Pathway

Cui, Yan; Liu, Jianfeng; Song, Yu; Chen, Chen; Shen, Yuehao; Xie, Keliang

doi:10.1111/cns.70305

High Concentration Hydrogen Protects Sepsis‐Associated Encephalopathy by Enhancing Pink1/Parkin‐Mediated Mitophagy and Inhibiting cGAS ‐ STING ‐ IRF3 Pathway

Background Sepsis‐associated encephalopathy (SAE) leads to increased mortality. Hydrogen (H 2 ) has been proven to be effective in protecting against SAE. This study aimed to investigate the protective mechanism of a high concentration of H 2 (HCH) (67%) against SAE. Methods A mouse sepsis model …