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Cited by 29Contact Dermatitis and AllergiesEffects and risks of endocrine disrupting chemicalsAntimicrobial agents and applications

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Preservatives in non‐cosmetic products: Increasing human exposure requires action for protection of health

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Lidén, Carola, Andersson, Niklas, White, Ian R.·2022·Contact Dermatitis
DOI 10.1111/cod.14181PMC PMC9796024
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Abstract

The widespread use of skin sensitizing preservatives is well‐known. Contact allergy to preservatives is often caused by their presence in cosmetic products. Preservative use in non‐cosmetic products is less well‐known. We have reviewed European Union (EU) legislations on classification and labelling, biocides and cosmetics, concerning conditions for use of the most used sensitizing preservatives (including formaldehyde‐releasing substances, isothiazolinones and parabens). We have analysed temporal trends in their use in non‐cosmetic products (tonnes, number of products, concentrations), based on annual reports to the Swedish Products Register 1995–2018; and we discuss implications for stakeholders. Major changes over time are that the use of most of the preservatives has increased by tonnes and/or by number of products, and that several use concentrations have declined following harmonized classification as a skin sensitizer with low concentration limits for this classification. We conclude that the massive increase in use of preservatives is alarming, and that urgent action is needed for protection of health. Their use in non‐cosmetic products is broad, increasing and often undisclosed. In the EU, legislations concerning chemicals can provide relevant restrictions to reduce their use and associated health risks, monitored by efficient surveillance. Prevention would be benefited by better coordination between legislations.

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  • In Europe, allergic reactions to cosmetics are increasing due to inadequate pre-sale risk assessment trials.

    “In Europe, allergic reactions to cosmetics are increasing due to inadequate pre-sale risk assessment trials.”

    From Allergens Causing Allergic Contact Dermatitis in Cosmetic Products: A Systematic Review (2024) · cites this paper as [4]

    The Introduction (page unavailable) reports that preservative allergy increased in Europe in previous decades and that cosmetic-use restrictions were followed by declines in many EU countries. The Discussion (page unavailable) describes problems with EU risk assessment, but the paper does not attribute the increase to inadequate pre-sale risk assessment trials. (LLM, conf=0.87)

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Metadata

Authors
Lidén, C., Andersson, N., & White, I. R.
Affiliations
  • Karolinska Institutet (SE)
  • Guy's Hospital (GB)
Corresponding author
Lidén, Carola
ORCID
Venue
Contact Dermatitis
Publisher
Wiley
Published
2022-07-18
Volume
87
Issue
5
Pages
389-405
ISSN
  • 0105-1873 (ISSN-L)
  • 1600-0536
DOI
10.1111/cod.14181
PMC
PMC9796024
OpenAlex
W4284888516
Cited by
29
References
1
Citations by year
2026: 7 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 1
FWCI
0.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Contact Dermatitis (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords
preservatives, skin sensitization, formaldehyde-releasing preservatives, isothiazolinones, parabens, chemical classification and labelling, human exposure, contact allergy
MeSH terms
Cosmetics, Disinfectants, Formaldehyde, Humans, Parabens, Preservatives, Pharmaceutical, Dermatitis, Allergic Contact

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