The DOI matches its Crossref record.
Mucocutaneous disorders in renal transplant recipients receiving sirolimus‐based immunosuppressive therapy: a prospective, case–control study
Abstract
Background Sirolimus (SRL) has some dermatologic complications including acneiform eruptions, edema, aphthous ulceration, and onychopathy. However, controlled studies reporting the prevalence and clinical characteristics of mucocutaneous disorders are scarce. Objective To investigate the prevalence and clinical spectrum of mucocutaneous disorders in renal transplant recipients (RTRs) receiving SRL and to compare the findings with those in RTRs not receiving SRL. Methods Fifty RTRs (35 men, 15 women; mean age, 34.6 ± 11.6 yr) receiving SRL, 50 RTRs (36 men, 14 women; mean age, 34.4 ± 11.3 yr) not on SRL were screened for mucocutaneous disorders. Results In RTRs receiving SRL, skin infection (78%) was the most common dermatologic disorder followed by facial hyperpigmentation (50%) and acneiform eruption (46%). Herpes simplex virus infections (14%) and seborrheic dermatitis (38%) were significantly more common in RTRs on SRL (p 0.05). Limitations This study had a small sample size. The investigator was not blinded to immunosuppressive treatment protocols. Conclusion Renal transplant recipients receiving SRL are more likely to develop seborrheic dermatitis and herpes simplex virus infections than those not taking SRL. Whereas, they are not more prone to edema, aphthous ulceration, acne, or longitudinal nail ridging.
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“SD is more prevalent in immune-compromised patients such as HIV/AIDS patients [7,10], organ transplant recipients [11,12], and patients with lymphoma [13].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [12]
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Cited by
Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
Metadata
- Authors
- Özcan, D., Seçkin, D., Ada, S., & Haberal, M.
- Affiliations
- Başkent University (TR)
- Corresponding author
- Özcan, Deren
- Venue
- Clinical Transplantation
- Publisher
- Wiley
- Published
- 2013-08-31
- Volume
- 27
- Issue
- 5
- Pages
- 742-748
- ISSN
- 0902-0063 (ISSN-L)
- 1399-0012
- OpenAlex
- W2089921447
- Cited by
- 15
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- rapamycin, kidney transplant recipients, mucocutaneous disease, seborrheic dermatitis, herpes simplex, skin infections, facial hyperpigmentation, acneiform eruption, edema, aphthous ulceration, immunosuppressive therapy adverse effects
- MeSH terms
- Adolescent, Adult, Female, Follow-Up Studies, Graft Rejection, Humans, Immunosuppressive Agents, Male, Middle Aged, Mucous Membrane, Prognosis, Prospective Studies, Risk Factors, Skin Diseases, Infectious, Case-Control Studies, Kidney Transplantation, Sirolimus, Young Adult
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