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Cited by 24Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesSpondyloarthritis Studies and Treatments

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Eczematized psoriasis – a frequent but often neglected variant of plaque psoriasis

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Lauffer, Felix, Eyerich, Kilian·2023·JDDG: Journal der Deutschen Dermatologischen Gesellschaft
DOI 10.1111/ddg.14991
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Abstract

Summary: Psoriasis is a common chronic inflammatory skin disease that causes systemic inflammation and severely impacts the patient's quality of life. Several highly effective therapeutics for psoriasis have been approved in recent years. However, in real life, a high proportion of patients either do not experience the clinical improvement observed in clinical trials or develop a secondary loss of efficacy. This may be a result of unrecognized endotypes of psoriasis that need to be characterized in greater depth to enable selection of an appropriate therapy. Eczematized psoriasis, which occurs in approximately 5–10% of patients with psoriasis, is an often‐neglected variant of psoriasis. The term “eczematized psoriasis” refers to patients developing psoriasis with similarities to eczema. These patients typically present with severe itching, and skin biopsies often reveal eosinophil granulocytes, serum crusts, or spongiosis, which are frequently observed in eczema. From an immunological perspective, additional signaling pathways that are responsible for eczema reactions might be activated in eczematized psoriasis compared to classical plaque psoriasis. This review summarizes the key clinical, histological, and immunological features of eczematized psoriasis, proposes diagnostic criteria, and evaluates the therapeutic options for eczematized psoriasis.

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Metadata

Authors
Lauffer, F., & Eyerich, K.
Affiliations
  • Technical University of Munich (DE)
  • University of Freiburg (DE)
Corresponding author
Lauffer, Felix
ORCID
Venue
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Publisher
Wiley
Published
2023-02-11
Volume
21
Issue
5
Pages
445-453
ISSN
  • 1610-0379 (ISSN-L)
  • 1610-0387
DOI
10.1111/ddg.14991
OpenAlex
W4320032700
Cited by
24
References
72
Citations by year
2026: 5 · 2025: 10 · 2024: 7 · 2023: 2
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
Locations
  • JDDG Journal der Deutschen Dermatologischen Gesellschaft (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Keywords
plaque psoriasis, pruritus, eosinophilic dermatitis, spongiosis, psoriasis diagnosis, psoriasis treatment
MeSH terms
Eczema, Humans, Pruritus, Psoriasis, Quality of Life, Skin Diseases

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