Causes of death in childhood‐onset Type 1 diabetes: long‐term follow‐up
Abstract
Aims To assess the causes of death and cause-specific standardized mortality ratios in two nationwide, population-based cohorts diagnosed with Type 1 diabetes during the periods 1973-1982 and 1989-2012, and to evaluate changes in causes of death during the follow-up period. Methods People with Type 1 diabetes who were aged Results During a mean (range) follow-up of 16.8 (0-40.7) years, 241 individuals (3.1%) died, representing 132 143 person-years. The leading cause of death before the age of 30 years was acute complications (41/119, 34.5%). After the age of 30 years cardiovascular disease was predominant (41/122, 33.6%), although death attributable to acute complications was still important in this age group (22/122, 18.0%). A total of 5% of deaths were caused by 'dead-in-bed' syndrome. The standardized mortality ratio was elevated for cardiovascular disease [11.9 (95% CI 8.6-16.4)] and violent death [1.7 (95% CI 1.3-2.1)] in both sexes combined, but was elevated for suicide only in women [2.5 (95% CI 1.2-5.3)]. The risk of death from acute complications was approximately half in women compared with men [hazard ratio 0.43 (95% CI 0.25-0.76)], and did not change with more recent year of diagnosis [hazard ratio 1.02 (0.98-1.05)]. Conclusions There was no change in mortality attributable to acute complications during the study period. To reduce premature mortality in people with childhood-onset diabetes focus should be on prevention of acute complications. Male gender implied i…
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Mortality from hypoglycemia in type 1 diabetes is not trivial.
“Mortality from hypoglycemia in type 1 diabetes is not trivial.”
One recent trial noted more than 8% of deaths for those younger than 56 years were from hypoglycemia.
“One recent trial noted more than 8% of deaths for those younger than 56 years were from hypoglycemia (107).”
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Glycemic Control and Excess Mortality in Type 1 Diabetes
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Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699 · see citing works
Amiel, S. A., Aschner, P., Childs, B., Cryer, P. E., de Galan, B. E., Frier, B. M., Gonder-Frederick, L., Heller, S. R., Jones, T., Khunti, K., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30315-2 · Cited by 526 · see citing works
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- Authors
- Gagnum, V., Stene, L. C., Jenssen, T. G., Berteussen, L. M., Sandvik, L., Joner, G., Njølstad, P. R., & Skrivarhaug, T.
- Affiliations
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- Haukeland University Hospital (NO)
- Corresponding author
- Gagnum, V.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2016-04-07
- Volume
- 34
- Issue
- 1
- Pages
- 56-63
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2297006579
- Cited by
- 87
- References
- 2
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 8 · 2020: 12 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 3
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Helse Sør-Øst RHF
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- type 1 diabetes, childhood-onset diabetes, causes of death, standardized mortality ratio, acute complications, cardiovascular disease, suicide, violent death, sex differences, premature mortality, long-term follow-up
- MeSH terms
- Adolescent, Cardiovascular Diseases, Child, Child, Preschool, Combined Modality Therapy, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Female, Follow-Up Studies, Humans, Infant, Male, Norway, Registries, Retrospective Studies, Severity of Illness Index, Sex Factors, Cohort Studies, Age of Onset, Diabetes Complications, Diabetic Cardiomyopathies, Mortality, Premature
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