Pharmacological treatment of diabetes in older people
Open accessAbstract
The pharmacological management of diabetes in older people is complex and challenging. It requires a comprehensive understanding of the individual beyond the diabetes itself. Through the ageing years, the older individual presents with diabetes-related and non-related comorbidities and complications, develops functional limitations and psychological issues, and may lack social support and access to care. A disturbance in these categories, known as the four geriatric domains, will negatively affect diabetes self-management and self-efficacy, leading to poor outcomes and complications. Furthermore, older people with diabetes may be more interested in the management of other chronic conditions such as pain or impaired mobility, and diabetes may be lower in their list of priorities. Proper education must be provided to the older individual and caregivers, with continuous monitoring and counselling, especially when pharmacological interventions offer risks of side effects, adverse reactions and interactions with other medications. Informed shared medical decisions will help to improve adherence to the regimen; however, such discussions ought to be based on the best evidence available, which is unfortunately limited in this age group. We performed a review focused on pharmacological agents and summarize current evidence on their use for the treatment of diabetes in older people. We encourage clinicians to investigate and incorporate the four geriatrics domains in the selection and…
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Older adults with diabetes may have cognitive impairment and functional impairment.
“Special care is required in prescribing and monitoring pharmacologic therapies in older adults (96), who are at high risk of polypharmacy, have difficulties in maintaining prescribed medication plans, and may have cognitive impairment and functional impairment.”
From 13. Older Adults: Standards of Care in Diabetes—2025 (2025) · cites this paper as [96]
Older adults with diabetes are at high risk of polypharmacy.
“Special care is required in prescribing and monitoring pharmacologic therapies in older adults (96), who are at high risk of polypharmacy, have difficulties in maintaining prescribed medication plans, and may have cognitive impairment and functional impairment.”
From 13. Older Adults: Standards of Care in Diabetes—2025 (2025) · cites this paper as [96]
Special care is required in prescribing and monitoring pharmacologic therapies in older adults.
“Special care is required in prescribing and monitoring pharmacologic therapies in older adults (96),”
From 13. Older Adults: Standards of Care in Diabetes—2025 (2025) · cites this paper as [96]
Older adults with diabetes have difficulties maintaining prescribed medication plans.
“Special care is required in prescribing and monitoring pharmacologic therapies in older adults (96), who are at high risk of polypharmacy, have difficulties in maintaining prescribed medication plans, and may have cognitive impairment and functional impairment.”
From 13. Older Adults: Standards of Care in Diabetes—2025 (2025) · cites this paper as [96]
Cites
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13. Older Adults: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s013 · Cited by 381 · see citing works
13. Older Adults: Standards of Care in Diabetes—2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Ekhlaspour, L., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s013 · Cited by 209 · see citing works
13. Older Adults: <i>Standards of Care in Diabetes—2024</i>
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s013 · Cited by 161 · see citing works
Metformin and ageing: improving ageing outcomes beyond glycaemic control
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Self-citation
- Authors
- Valencia, W. M., & Florez, H.
- Affiliations
- University of Miami (US)
- Corresponding author
- Valencia, W. M.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2014-09-11
- Volume
- 16
- Issue
- 12
- Pages
- 1192-1203
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2047362353
- Cited by
- 62
- References
- 6
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- pharmacotherapy, antidiabetic drugs, comorbidities, functional limitations, diabetes self-management, self-efficacy, adverse drug reactions, drug interactions, shared decision-making, medication adherence, patient education
- MeSH terms
- Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Diabetes Mellitus, Drug Interactions, Health Services Accessibility, Humans, Hypoglycemic Agents, Patient Education as Topic, Quality of Life, Risk Factors, Self Care, Social Support, Comorbidity, Disease Progression, Polypharmacy, Diabetes Complications, Medication Adherence, Health Literacy
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