Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin‐treated type 1 and type 2 diabetes: the global HAT study

Khunti, K., Alsifri, S., Aronson, R., Cigrovski Berković, M., Enters‐Weijnen, C., Forsén, T., Galstyan, G., Geelhoed‐Duijvestijn, P., Goldfracht, M., Gydesen, H., Kapur, R., Lalic, N., Ludvik, B., Moberg, E., Pedersen‐Bjergaard, U., Ramachandran, A., on behalf of the HAT Investigator Group·2016·Diabetes Obesity and Metabolism

DOI 10.1111/dom.12689

Cited by (275)

Items 101–200 of 275

DEVOTE 5: Evaluating the Short-Term Cost-Utility of Insulin Degludec Versus Insulin Glargine U100 in Basal–Bolus Regimens for Type 2 Diabetes in the UK
Richard Fulton Pollock, William J. Valentine, Steven P. Marso, Jens Gundgaard, Nino Hallén, Lars Hansen, Deniz Tutkunkardas, John B. Buse, On behalf of the DEVOTE Study Group · 2018 · Diabetes Therapy
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Søren Tang Knudsen, Annunziata Lapolla, Bernd Schultes, Nikolaοs Tentolouris, Andrei‐Mircea Catarig, Michael Lyng Wolden, Thorsten Siegmund · 2019 · Diabetic Medicine
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Xiling Hu, Weiran Xu, Shuo Lin, Cang Zhang, Cong Ling, Miaoxia Chen · 2020 · Journal of Diabetes Research
Unmet support needs relating to hypoglycaemia among adults with type 1 diabetes: Results of a multi‐country web‐based qualitative study
Hannah Chatwin, Melanie M Broadley, Christel Hendrieckx, Jill Carlton, Simon R. Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Norbert Hermanns, Katharina Finke-Gröne, Jane Speight et al. · 2021 · Diabetic Medicine
Predictive Modeling of Hypoglycemia Risk with Basal Insulin Use in Type 2 Diabetes: Use of Machine Learning in the LIGHTNING Study
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Relationship between hypoglycaemia, body mass index and quality of life among patients with type 1 diabetes: Observations from the DEPICT clinical trial programme
Jason P. Gordon, LEE M. BERESFORD-HULME, Hayley Bennett, Amarjeet Tank, Christopher Edmonds, Phil C. McEwan · 2020 · Diabetes Obesity and Metabolism
Cost-Effectiveness of Insulin Degludec Versus Insulin Glargine U300 in the Netherlands: Evidence From a Randomised Controlled Trial
Marc Evans, Robert Gerald Jan Moes, Katrine Seide Pedersen, Jens Gundgaard, Thomas Rudolf Pieber · 2020 · Advances in Therapy
A Comparison of the Rates of Clock-Based Nocturnal Hypoglycemia and Hypoglycemia While Asleep Among People Living with Diabetes: Findings from the Hypo-METRICS Study
Gilberte Martine‐Edith, Patrick Divilly, Natalie Zaremba, Uffe Søholm, Melanie M Broadley, Petra Martina Baumann, ZEINAB MAHMOUDI, Mikel Gomes, Namam Ali, Evertine J. Abbink et al. · 2024 · Diabetes Technology & Therapeutics
Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin‐treated type 2 diabetes: The Fukuoka Diabetes Registry
Masanori Iwase, Yuji Komorita, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono · 2020 · Journal of Diabetes Investigation
Dead in bed – A systematic review of overnight deaths in type 1 diabetes
Jessica Jones, Steven James, Fran Brown, David Norman O'Neal, Elif Ilhan Ekinci · 2022 · Diabetes Research and Clinical Practice
Improved Glycemic Control with Insulin Glargine 300 U/mL (Toujeo®) in Patients with Type 2 Diabetes: Real-World Effectiveness in Switzerland
Peter Wiesli, Marcus Schories · 2018 · Diabetes Therapy
The Impact of Flash Glucose Monitoring on Markers of Glycaemic Control and Patient Satisfaction in Type 2 Diabetes
Ayman Al Hayek, Mohamed Abdulaziz Al Dawish, Manal El Jammal · 2021 · Cureus
Insulin Therapy and Outcome of Coronavirus Disease 2019 (COVID-19): A Systematic Review, Meta-Analysis, and Meta-Regression
Timotius Ivan Hariyanto, Nata Pratama Hardjo Lugito, Theo Audi Yanto, Jeremia Immanuel Siregar, Andree Kurniawan · 2021 · Endocrine Metabolic & Immune Disorders - Drug Targets
Spontaneous and iatrogenic hypoglycemia in cystic fibrosis
Rebecca A. Hicks, Brynn E. Marks, Rachael Oxman, Amir A. Moheet · 2021 · Journal of Clinical & Translational Endocrinology
Regional variations in definitions and rates of hypoglycaemia: findings from the global HAT observational study of 27 585 people with Type 1 and insulin‐treated Type 2 diabetes mellitus
Kamlesh Khunti, Maja Cigrovski Berković, Bernhard H. Ludvik, E. Moberg, Jesper Barner Lekdorf, Helge Gydesen, Ulrik Pedersen‐Bjergaard · 2018 · Diabetic Medicine
The Clinical Impact of Flash Glucose Monitoring—a Digital Health App and Smartwatch Technology in Patients With Type 2 Diabetes: Scoping Review
Sergio Diez Alvarez, Antoni Fellas, Derek Santos, Dean Sculley, Katie Wynne, Shamasunder Acharya, Pooshan D. Navathe, Xavier Gironès, Andrea Coda · 2023 · JMIR Diabetes
Predictive factors of hypoglycemia in type 2 diabetes: a prospective study using machine learning
Motahare Shabestari, Akram Mehrabbeik, Sebastiano Barbieri, Pedro Manuel Marques-Vidal, Poria Heshmati-Nasab, Reyhaneh Azizi · 2025 · Scientific Reports
Machine learning-based prediction of hypoglycemia severity in hospitalized diabetic patients
Hongjian Jia, Jietao Zhang · 2025 · Frontiers in Endocrinology
Quality-of-life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec
Edurne Lecumberri, Maite Ortega, Marta Iturregui, José A. Quesada, Clotilde Vázquez, Domingo Orozco‐Beltrán · 2018 · Current Medical Research and Opinion
Cost-Effectiveness of Insulin Degludec Versus Insulin Glargine U100 in Patients with Type 1 and Type 2 Diabetes Mellitus in Serbia
Nebojsa M. Lalic, Monika Russel-Szymczyk, Marina Culic, Christian Klyver Tikkanen, Barrie Chubb · 2018 · Diabetes Therapy
Systematic Literature Review and Indirect Treatment Comparison of Three Ready-to-Use Glucagon Treatments for Severe Hypoglycemia
Marga Giménez, Kamlesh Khunti, Munehide Matsuhisa, Suresh Chenji, Kristen E. Syring, Yu Yan · 2023 · Diabetes Therapy
Self-reported Hypoglycaemic Events in 2 430 Patients with Insulin-treated Diabetes in the German Sub-population of the HAT Study
Werner Kern, Andreas Holstein, Christian Moenninghoff, Joachim Kienhöfer, Matthias Riedl, Bernhard Kulzer · 2017 · Experimental and Clinical Endocrinology & Diabetes
Type 2 diabetes patients’ views on prevention of hypoglycaemia – a mixed methods study investigating self-management issues and self-identified causes of hypoglycaemia
Stijn Crutzen, Tessa van den Born-Bondt, Petra Denig, Katja Taxis · 2021 · BMC Family Practice
Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions
Quang Duy Trinh, Kazuhide Takada, Ngan Thi Kim Pham, Chika Takano, Takahiro Namiki, Ryo Ikuta, Shingo Hayashida, Shoko Okitsu, Hiroshi Ushijima, Shihoko Komine‐Aizawa et al. · 2022 · Frontiers in Microbiology
Efficacy and safety of the second generation basal insulin analogs in type 2 diabetes mellitus: A critical appraisal
Hernando Vargas‐Uricoechea, Frias Juan Pablo · 2019 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
A Scalable Application of Artificial Intelligence-Driven Insulin Titration Program to Transform Type 2 Diabetes Management
Mark Warren, Richard M. Bergenstal, Matthew Hager, Eran Bashan, Israel Hodish · 2024 · Diabetes Technology & Therapeutics
The challenge of assessing impaired awareness of hypoglycaemia in diabetes in the era of continuous glucose monitoring: A narrative review of evidence and translation into clinical practice
Simon A. Berry, Alexandros Leonidas Liarakos, Vaios Koutroukas, Pratik Choudhary, Emma G. Wilmot, Ahmed Iqbal · 2025 · Diabetes Obesity and Metabolism
Epidemiological, Social and Economic Burden of Severe Hypoglycaemia in Patients with Diabetes Mellitus in Portugal: A Structured Literature Review
Ana Rita Soares, Marisa Coelho, Marsha Tracey, Davide Maurício Carvalho, José Silva‐Nunes · 2023 · Diabetes Therapy
The economic impact of insulin-related hypoglycemia in Denmark: an analysis using the Local Impact of Hypoglycemia Tool
Nicki Hoskins, Christian Klyver Tikkanen, Ulrik Pedersen‐Bjergaard · 2016 · Journal of Medical Economics
GP-OSMOTIC trial protocol: an individually randomised controlled trial to determine the effect of retrospective continuous glucose monitoring (r-CGM) on HbA1c in adults with type 2 diabetes in general practice
John Furler, David Norman O'Neal, Jane Speight, Irene Blackberry, Jo-Anne Elizabeth Manski-Nankervis, Sharmala Thuraisingam, Katie De La Rue, Louise Ginnivan, Jessica L. Browne, Elizabeth Holmes‐Truscott et al. · 2018 · BMJ Open
Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria
Monika Russel-Szymczyk, Vasil Valov, Alexandra Savova, Manoela M. Manova · 2019 · BMC Endocrine Disorders
Temporary Reductions in Insulin Requirements Are Associated with Hypoglycemia in Type 2 Diabetes
Roy Harper, Eran Bashan, Stanley G. Bisgaier, M. F. Willis, Deanna J. M. Isaman, Israel Hodish · 2018 · Diabetes Technology & Therapeutics
Effectiveness of Insulin Degludec in Thai Patients with Diabetes Mellitus: Real-World Evidence From a Specialized Diabetes Center
Yotsapon Thewjitcharoen, Nalin Yenseung, Areeya Malidaeng, Siriwan Butadej, Phawinpon Chotwanvirat, Sirinate Krittiyawong, Chattip Thammawiwat, Thep Himathongkam · 2019 · Experimental and Clinical Endocrinology & Diabetes
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Yana Anfinogenova, Elena V. Grakova, Maria Shvedova, K. V. Kopeva, Alexander T. Teplyakov, Sergey Valentinovich Popov · 2017 · Heart Failure Reviews
Perspectives of Patients with Insulin-Treated Type 1 and Type 2 Diabetes on Hypoglycemia: Results of the HAT Observational Study in Central and Eastern European Countries
Martin Haluzı́k, Adam Jacek Kretowski, Krzysztof Strojek, Leszek Czupryniak, Andrej Janež, Péter Kempler, Michal Anděl, Tsvetalina I. Tankova, Mihail Boyanov, Lea Smircic Duvnjak et al. · 2018 · Diabetes Therapy
Latent Profile Analysis of Fear of Hypoglycemia in Middle-Aged and Elderly Hospitalized Patients with Type 2 Diabetes and Its Relationship with Sleep Quality
Junxian Xu, Suhong Xiao, Xiaoyun Xie, Yunqin Kang, Donghong Peng, Yanhong Lu · 2023 · Diabetes Metabolic Syndrome and Obesity
Development and Validation of a Nocturnal Hypoglycaemia Risk Model for Patients With Type 2 Diabetes Mellitus
Chen Gong, Tingting Cai, Ying Wang, Xuelian Xiong, Yunfeng Zhou, Tingting Zhou, Qi Sun, Huiqun Huang · 2024 · Nursing Open
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Xinyi He, Zimo Zhao, Yan Sun, Xi Jiang · 2025 · European Journal of Medicinal Chemistry
MDI versus CSII in Chinese adults with type 1 diabetes in a real-world situation: based on propensity score matching method
Jian Ming Yu, Hong Wang, Min Zhu, Jingjing Xu · 2024 · Health and Quality of Life Outcomes
Emergency attendance for acute hyper- and hypoglycaemia in the adult diabetic population of the metropolitan area of Milan: quantifying the phenomenon and studying its predictors
Anita Andreano, Marco Bosio, Antonio Giampiero Russo · 2020 · BMC Endocrine Disorders
Continuous glucose monitoring demonstrates low risk of clinically significant hypoglycemia associated with sulphonylurea treatment in an African type 2 diabetes population: results from the OPTIMAL observational multicenter study
Anxious Jackson Niwaha, Lauren R. Rodgers, Alice L. J. Carr, Priscilla Balungi, Raymond Mbayo Mwebaze, Andrew Tym Hattersley, Beverley M. Shields, Moffat Nyirenda, Angus G. Jones · 2022 · BMJ Open Diabetes Research & Care
Burden and Coping Strategies of Hypoglycemia in People with Diabetes
Aris Liakos, Thomas Karagiannis, Ioannis Avgerinos, Απόστολος Τσάπας, Eleni Bekiari · 2023 · Current Diabetes Reviews
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Budget impact analysis of continuous glucose monitoring in individuals with type 2 diabetes on insulin treatment in England
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Comprehensive evaluation of patterns of hypoglycemia unawareness (HUA) and glycemic variability (GV) in patients with fibrocalculous pancreatic diabetes (FCPD): A cross-sectional study from South India
Riddhi Dasgupta, Felix Jebasingh, Shajith Anoop S, Santhya Seenivasan, Mathews Edatharayil Kurian, Flory Christina, Gracy Varghese, Pamela Christudoss, K. U. Lijesh, Deepu David et al. · 2022 · PLoS ONE
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Nicole M Ehrhardt, Vanita R. Aroda, Rodolfo Javier Galindo, Anne L. Peters, Jay H. Shubrook · 2023 · Clinical Diabetes
A cross-sectional questionnaire study: Impaired awareness of hypoglycaemia remains prevalent in adults with type 1 diabetes and is associated with the risk of severe hypoglycaemia
Faye Baxter, Nicola Baillie, Anna R. Dover, Roland H. Stimson, Fraser W. Gibb, Shareen Forbes · 2024 · PLoS ONE
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Ngiap Chuan Tan, Su‐Yen Goh, Ey Khoo, Rinkoo Dalan, A Koong, Khoo CM, TS Tan, AB Jain, A. Gadekar, YM Bee et al. · 2019 · Singapore Medical Journal
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Incidence of hypoglycaemia in the South African population with diabetes: results from the IDMPS Wave 7 study
Hilton Kaplan, Aslam Amod, F H Van Zyl, Jeevren Reddy, Alet van Tonder, Ellina Tsymbal, Alicia McMaster · 2019 · Journal of Endocrinology Metabolism and Diabetes of South Africa
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Athena Philis‐Tsimikas, Wendy S. Lane, Ulrik Pedersen‐Bjergaard, Carol Wysham, Lars Bardtrum, Signe Harring Østoft, Simon R. Heller · 2020 · Diabetes Obesity and Metabolism
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Q X Zhang, Haojie Zhou, Ruonan Lin, Liping Hu, Xiaoli Zhu · 2025 · BMC Endocrine Disorders
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Haowen Hsu, Paul T. Kocis, Ariana R Pichardo-Lowden, Wenke Hwang · 2024 · Journal of Diabetes
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Sérgio Atala Dib · 2022 · Archives of Endocrinology and Metabolism
Brain Regulation of Cardiac Function during Hypoglycemia
Matthew E. Chambers, Emily H. Nuibe, Candace M. Reno · 2023 · Metabolites
Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel
Ádám Gyula Tabák, Péter Kempler, Cristian Guja, Roy Eldor, Martin Haluzı́k, Tomasz Klupa, Νικόλαος Παπάνας, Anca Pantea Stoian, Boris Mankovsky · 2024 · Diabetes Therapy
Hypoglycemia in Type 1 Diabetes Mellitus
Kenan Şakar, Neşe Çınar · 2024 · IntechOpen eBooks
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Fraser James Pirie, Vishal Jairam, Imran M. Paruk, Cathy Connolly, Ayesha Ahmed Motala · 2019 · Diabetes Research and Clinical Practice
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Melanie M Broadley, Hannah Chatwin, Uffe Søholm, Stephanie A. Amiel, Jill Carlton, Bastiaan E. de Galan, Christel Hendrieckx, Rory J. McCrimmon, Soren Eik Skovlund, Frans Pouwer et al. · 2022 · BMJ Open Diabetes Research & Care
Expert Group Recommendations on Detection and Management of Hypoglycemia in Routine Clinical Practice in Insulin Treated Patients with Diabetes.
Awadhesh Kumar Singh, Pradeep Talwalkar, Abhay I Ahluwalia, Kirtikumar D Modi, Banshi Saboo · 2018 · PubMed
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M. A. K. Omar, Adri Kok, Duma Khutsoane, Shaifali Joshi, Michael Ramaboea, Makepisi Lesiba Isaac Mashitisho, Verushka Chetty, Levi John Koopman, Louise Johnson, on behalf of the IO HAT investigator group · 2017 · Journal of Endocrinology Metabolism and Diabetes of South Africa
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