The DOI matches its Crossref record; 16 of the 17 references it cites were found in a registry or an index.
A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
Abstract
Acne vulgaris is a chronic inflammatory skin disease that mostly develops during adolescence and continues throughout adulthood. It affects the face, the main location of cosmetic appearance. Despite many developments in acne treatment, various combination therapies are needed to create the best option. Ninety patients were included in this study. We used the global acne grading system (GAGS) and the lesion counting and photographic standards that were used by Hayashi et al., to assess acne severity. The patients were randomly divided into three groups as group 1 (using only 5% BPO, twice a day), group 2 (using only the combination of 5% BPO + 3% erythromycin, twice a day), and group 3 (using only the combination of 4% niacinamide + 1% gallic acid + 1% lauric acid, twice a day). Thirty patients were included in each group. The scores were evaluated at weeks 0, 2, 4 and 8, and compared with each other. As a result of the study, all three treatment types were found to be effective. The combination of 4% niacinamide + 1% gallic acid + 1% lauric acid can be used as an alternative topical treatment for acne vulgaris to prevent resistance against topical antibiotics and the side effects of some other treatments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Three of the lower quality studies reported significantly superior improvements in the acne lesion counts compared to placebo or comparators”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“the remaining three with no comparators reported 40%–80% improvement in global scoring.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“Two of the non‐RCTs reported significantly superior improvements in the global assessment versus comparators or placebo”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
In the citing paper
“the remainder had no comparator arms but reported reductions of 40%–95% in acne lesions.”
From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [21]
Citations
Cites
Thiboutot, D. M., Gollnick, H. P. M., Bettoli, V., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. R., Lozada, V. T., Berson, D. S., Finlay, A. Y., et al. (2009) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.01.019 · Cited by 865
A comparison of current acne grading systems and proposal of a novel system
Doshi, A., Zaheer, A., & Stiller, M. J. (1997) · International Journal of Dermatology · doi:10.1046/j.1365-4362.1997.00099.x · Cited by 670
Establishment of grading criteria for acne severity
Hayashi, N., Akamatsu, H., Kawashima, M., & Acne Study Group (2008) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2007.00403.x-i1 · Cited by 161
The role of topical dermocosmetics in acne vulgaris
Araviiskaia, E., & Dréno, B. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13579 · Cited by 123
Chalker, D. K., Shalita, A. R., Smith, J. G., & Swann, R. W. (1983) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(83)70211-2 · Cited by 97
Sharma, R., Kishore, N., Hussein, A. A., & Lall, N. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-292 · Cited by 84
den Ley, J. J., Hickman, J. G., Jarratt, M. T., Stewart, D. M., & Levy, S. F. (2001) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347540100500109 · Cited by 82
The role of nicotinamide in acne treatment
Walocko, F. M., Eber, A. E., Keri, J. E., Alharbi, M. A., & Nouri, K. (2017) · Dermatologic Therapy · doi:10.1111/dth.12481 · Cited by 64
Diseases of the Sebaceous Glands
Braun‐Falco, O., Plewig, G., Wolff, H. H., & Burgdorf, W. H. C. (2000) · Springer eBooks · doi:10.1007/978-3-642-97931-6_28 · Cited by 51
Chu, A. C., HUBER, F. J., & Plott, R. T. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.d01-1176.x · Cited by 35
Chu, A. C., HUBER, F. J., & Plott, R. T. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb14903.x · Cited by 28
Intense pulsed light versus benzoyl peroxide 5 % gel in treatment of acne vulgaris
Abdel-latif, A. A., Hassan, F. A. A., Elshahid, A. R., Mohamed, A., & Elsaie, M. L. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1440-0 · Cited by 26
Tunca, M., Akar, A., Ozmen, I., & Erbil, H. (2010) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2010.04601.x · Cited by 17
Ibrahim, F. A., El‐Deen, A. K., Abass, S. A. E., & Shimizu, K. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.09.009 · Cited by 15
Akne Vulgaris'in Psikiyatrik Etkileri
Öztürk, A. (2014) · DergiPark (Istanbul University) · doi:10.18229/ktd.16909 · Cited by 1
Postadolesan aknenin akne spektrumu içindeki yeri
Kapulu, N., Ermertcan, A. T., Şahin, M. T., İnanır, I., & Öztürkcan, S. (2003) · Cited by 1
Research works printed but not linked: 1
- Tuzun Y, 2004, Güncel Akne Tedavisi, Dermatose, 3, 220
Cited by
Cano, R., Bermúdez, V., Galbán, N., Garrido, B., Santeliz, R., Gotera, M. P., Durán, P., Boscan, A., Carbonell, A., Durán‐Agüero, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169118 · Cited by 66
A Comprehensive Update on the Bioactive Compounds from Seagrasses
Gono, C. M. P., Ahmadi, P., Hertiani, T., Septiana, E., Putra, M. Y., & Chianese, G. (2022) · Marine Drugs · doi:10.3390/md20070406 · Cited by 54
Garduño-Jiménez, A.-L., Durán–Álvarez, J. C., Ortori, C. A., Abdelrazig, S., Barrett, D. A., & Gomes, R. L. (2023) · Water Research · doi:10.1016/j.watres.2023.119903 · Cited by 55
Niacinamide: a review on dermal delivery strategies and clinical evidence
Ong, R. R., & Goh, C. F. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01593-y · Cited by 44
“Furthermore, acne, a distinctive inflammatory skin condition, was also explored, with 7% of the studies indicating a reduction in acne lesion counts, a lowered acne severity and an improved grading score [14, 15, 75, 77].”
International expert consensus recommendations for the use of dermocosmetics in acne.
Thiboutot, D., Layton, A. M., Traore, I., Gontijo, G., Troielli, P., Ju, Q., Kurokawa, I., & Dreno, B. (2025) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20145 · Cited by 32
Metadata
- Authors
- Kozan, A., Guner, R. Y., & Akyol, M.
- Affiliations
- Amasya Üniversitesi (TR)
- Dermatology Department Cumhuriyet University School of Medicine Sivas Turkey
- Sivas Cumhuriyet Üniversitesi (TR)
- Venue
- Dermatologic Therapy
- Publisher
- Wiley
- Published
- 2020-06-25
- Volume
- 33
- Issue
- 4
- Pages
- e13534-e13534
- ISSN
- 1396-0296 (ISSN-L)
- 1529-8019
- OpenAlex
- W3023836922
- Cited by
- 15
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Dermatologic Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- acne, benzoyl peroxide, nicotinamide, gallic acid, lauric acid, erythromycin, topical combination therapy, acne severity assessment, Global Acne Grading System, antibiotic resistance prevention, treatment efficacy
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Anti-Bacterial Agents, Benzoyl Peroxide, Dermatologic Agents, Erythromycin, Gallic Acid, Gels, Humans, Lauric Acids, Niacinamide, Retrospective Studies, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
