Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

Cleavage of amyloid‐β precursor protein ( APP ) at the Asp1 β‐secretase site of the amyloid‐β protein (Aβ) domain by β‐site Aβ precursor protein‐cleaving enzyme 1 ( BACE 1) is required for the generation of Aβ, a central component of neuritic plaques in the Alzheimer's disease ( AD ) brain. In th…