Tonically active NMDA receptors – a signalling mechanism critical for interneuronal excitability in the CA 1 stratum radiatum

Riebe, Ilse; Seth, Henrik; Culley, Georgia; Dósa, Zita; Radi, Shayma; Strand, Karin; Fröjd, Victoria; Hanse, Eric

doi:10.1111/ejn.13128

Tonically active NMDA receptors – a signalling mechanism critical for interneuronal excitability in the CA 1 stratum radiatum

In contrast to tonic extrasynaptic γ‐aminobutyric acid ( GABA ) A receptor‐mediated signalling, the physiological significance of tonic extrasynaptic N ‐methyl‐ d ‐aspartate ( NMDA ) receptor ( NMDAR )‐mediated signalling remains uncertain. In this study, reversible open‐channel blockers of NMDAR…