Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity.
Abstract
This population-based longitudinal prospective cohort study, conducted in a selected population of community-dwelling middle-aged and older adults living in a rural village severely struck by the SARS-CoV-2 pandemic, demonstrates that individuals with a history of mild symptomatic SARS-CoV-2 infections have more than 18 times the odds of developing late substantial cognitive decline than those without clinical and serological evidence of the infection.
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Persistent systemic inflammation following SARS-CoV-2 infection worsens neurodegeneration, which may cause long-term cognitive deficits.
“Chronic systemic inflammation after SARS-CoV-2 infection exacerbates neurodegeneration, thus potentially leading to long-term cognitive deficits.”
From One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study (2022) · cites this paper as [35]
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Collaborators, G. B. O. D. L. C., Hanson, S. W., Abbafati, C., Aerts, J. G. J. V., Al‐Aly, Z., Ashbaugh, C., Ballouz, T., Blyuss, O. B., Bobkova, P., Bonsel, G. J., et al. (2022) · JAMA · doi:10.1001/jama.2022.18931 · Cited by 989 · see citing works
Liu, Y.-H., Chen, Y., Wang, Q.-H., Wang, L.-R., Jiang, L., Yang, Y., Chen, X., Li, Y., Cen, Y., Xu, C., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0461 · Cited by 225 · see citing works
Nersesjan, V., Fonsmark, L., Christensen, R. H. B., Amiri, M., Mérie, C., Lebech, A., Katzenstein, T. L., Bang, L. E., Kjærgaard, J., Kondziella, D., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.0284 · Cited by 72 · see citing works
Bridging Knowledge Gaps in the Diagnosis and Management of Neuropsychiatric Sequelae of COVID-19
Frontera, J. A., & Simon, N. M. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.1616 · Cited by 72 · see citing works
Edén, A., Grahn, A., Bremell, D., Aghvanyan, A., Bathala, P., Fuchs, D., Gostner, J. M., Hagberg, L., Kanberg, N., Kanjananimmanont, S., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.13253 · Cited by 59 · see citing works
Outcomes of COVID-19 Infection and Vaccination Among Individuals With Myasthenia Gravis
Alcántara, M., Koh, M., Park, A. L., Bril, V., & Barnett, C. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.9834 · Cited by 24 · see citing works
Vaccine Safety and Immunogenicity in Patients With Multiple Sclerosis Treated With Natalizumab
Carvajal, R., Zabalza, A., Carbonell‐Mirabent, P., Martínez‐Gómez, X., Esperalba, J., Pappolla, A., Rando‐Segura, A., Cobo‐Calvo, Á., Tur, C., Rodríguez, M., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.6345 · Cited by 15 · see citing works
Gong, S., Deng, B., Yu, H., Zhang, X., Yang, W., & Chen, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1499082 · Cited by 6 · see citing works
- Authors
- Virhammar
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2021-10
- Volume
- 28
- Issue
- 10
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W4244790050
- Cited by
- 8
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 5
- Type
- paratext
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, cognitive decline, serological evidence of infection, middle-aged and older adults, rural population, long COVID, post-COVID cognitive impairment
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