Skin microbiota and human 3D skin models
Abstract
Although the role of the microbiota in skin homeostasis is still emerging, there is growing evidence that an intact microbiota supports the skin barrier. The increasing number of research efforts that are trying to shed more light on the human skin-microbiota interaction requires the use of suitable experimental models. Three-dimensional (3D) skin equivalents have been established as a valuable tool in dermatological research because they contain a fully differentiated epidermal barrier that reflects the morphological and molecular characteristics of normal human epidermis. In this review, we provide an overview of current 3D skin models and illustrate the potential of 3D skin models to study the human skin-microbiota interplay.
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Adding the complete microbiota to colonize the apical side of human skin models would make them closer to the in vivo condition.
“For this reason, it is to be foreseen to improve human skin models by adding the complete microbiota to colonize the apical side of the model in order to get closer and closer to the in vivo condition [130,131,132].”
From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [131]
Cites
Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095 · see citing works
Lai, Y., Cogen, A. L., Radek, K. A., Park, H. J., MacLeod, D. T., Leichtle, A., Ryan, A. F., Di Nardo, A., & Gallo, R. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.123 · Cited by 446 · see citing works
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Rouanet, A., Bolca, S., Bru, A., Claes, I., Cvejic, H., Girgis, H., Harper, A., Lavergne, S. N., Mathys, S., Pane, M., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00237 · Cited by 120 · see citing works
Loomis, K. H., Wu, S. K., Ernlund, A., Zudock, K., Reno, A., Blount, K., & Karig, D. K. (2021) · Microbiome · doi:10.1186/s40168-020-00963-1 · Cited by 74 · see citing works
Mieremet, A., Vázquez García, A., Boiten, W., van Dijk, R., Gooris, G., Bouwstra, J. A., & El Ghalbzouri, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-44204-4 · Cited by 42 · see citing works
Non-Melanoma Skin Cancer: news from microbiota research
Squarzanti, D. F., Zavattaro, E., Pizzimenti, S., Amoruso, A., Savoia, P., & Azzimonti, B. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1794792 · Cited by 40 · see citing works
Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?
Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11 · see citing works
- Authors
- Rademacher, F., Simanski, M., Gläser, R., & Harder, J.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- Corresponding author
- Harder, Jürgen
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2018-04-10
- Volume
- 27
- Issue
- 5
- Pages
- 489-494
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2791025208
- Cited by
- 64
- References
- 2
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 5 · 2021: 9 · 2020: 14 · 2019: 4
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- skin microbiome, 3D skin equivalents, skin barrier, skin homeostasis, in vitro skin model
- MeSH terms
- Humans, Models, Biological, Skin, In Vitro Techniques
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