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Cited by 78melanin and skin pigmentationHair Growth and DisordersMelanoma and MAPK Pathways

Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials

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Qiu, Weiming, Chuong, Cheng‐Ming, Lei, Mingxing·2019·Experimental Dermatology
DOI 10.1111/exd.13856PMC PMC6488374
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Abstract

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate and keep quiescence to control and coordinate tissue homeostasis, repair and regeneration. In synchrony with hair follicle stem cells, melanocyte stem cells in the hair follicles undergo cyclic activation, degeneration and resting phases, to pigment the hairs and to preserve the stem cells. Disorder of melanocytes results in severe skin problems such as canities, vitiligo and even melanoma. Here, we compare and summarize recent discoveries about melanocyte in the skin, particularly in the hair follicle. A better understanding of the physiological and pathological regulation of melanocyte and melanocyte stem cell behaviours will help to guide the clinical applications in regenerative medicine.

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  • The cells used contained melanoblasts, which differentiate into melanocyte stem cells following melanocytes in the hair matrix.

    “The cells used contained melanoblasts (37), which differentiate into melanocyte stem cells following melanocytes in the hair matrix.”

    From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [37]

    The Introduction says melanoblasts differentiate into melanocyte stem cells in the hair-follicle bulge, and that these stem cells give rise to mature melanocytes in the hair matrix. The paper does not establish that the citing study’s cells contained melanoblasts; nor does it describe stem cells arising after hair-matrix melanocytes. (LLM, conf=0.80)

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Cited by

Sorted by citations

Authors
Qiu, W., Chuong, C., & Lei, M.
Affiliations
  • Chinese People's Liberation Army (CN)
  • University of Southern California (US)
  • China Medical University (TW)
Corresponding author
  • Chuong, Cheng‐Ming
  • Lei, Mingxing
ORCID
Venue
Experimental Dermatology
Publisher
Wiley
Published
2019-01-15
Volume
28
Issue
4
Pages
395-405
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
DOI
10.1111/exd.13856
PMC
PMC6488374
OpenAlex
W2904163545
Cited by
78
References
8
Citations by year
2026: 7 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 1
FWCI
0.62
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • China Postdoctoral Science Foundation (2016M590866)
  • National Natural Science Foundation of China (81602782)
  • National Institutes of Health (AR 047364, AR 060306, GM125322)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords
melanocyte stem cells, skin pigmentation, hair follicle, melanocyte differentiation, stem cell quiescence, hair follicle stem cells, tissue homeostasis, hair regrowth, canities, vitiligo, melanoma, regenerative medicine, stem cell therapy
MeSH terms
Animals, Feathers, Humans, Melanocytes, Skin Pigmentation, Wound Healing, Signal Transduction, Keratinocytes, Hypopigmentation, Hair Follicle, Adult Stem Cells

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