Tumour suppressor p16 INK4a – anoikis‐favouring decrease in N/O‐glycan/cell surface sialylation by down‐regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

Amano, Maho; Eriksson, Hanna; Manning, Joachim C.; Detjen, Katharina M.; André, Sabine; Nishimura, Shin‐Ichiro; Lehtiö, Janne; Gabius, Hans‐Joachim

doi:10.1111/febs.12001

Tumour suppressor p16 INK4a – anoikis‐favouring decrease in N/O‐glycan/cell surface sialylation by down‐regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

Tumour suppressor p16 INK4a is known to exert cell‐cycle control via cyclin‐dependent kinases. An emerging aspect of its functionality is the orchestrated modulation of N / O ‐glycosylation and galectin expression to induce anoikis in human C apan‐1 pancreatic carcinoma cells. Using chemoselectiv…