Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I

Moreno‐Sánchez, Rafael; Hernández‐Esquivel, Luz; Rivero‐Segura, Nadia A.; Marín‐Hernández, Alvaro; Neuzil, Jiri; Ralph, Stephen J.; Rodríguez‐Enríquez, Sara

doi:10.1111/febs.12086

Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I

Succinate‐driven oxidation via complex II ( CII ) may have a significant contribution towards the high rates of production of reactive oxygen species ( ROS ) by mitochondria. Here, we show that the CII Q site inhibitor thenoyltrifluoroacetone (TTFA) blocks succinate + rotenone‐driven ROS producti…