Molecular mechanisms regulating Proteinase-Activated Receptors (PARs)

Cites (238)

Items 201–238 of 238

1. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects
   Charlotte Avet, Claudio F. Sturino, Sébastien Grastilleur et al. · 2020 · Communications Biology
2. Unproductive cleavage and the inactivation of protease‐activated receptor‐1 by trypsin in vascular endothelial cells
   Tetsuzo Nakayama, Katsuya Hirano, Yoshinobu Shintani · 2003 · British Journal of Pharmacology
3. Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis
   Elena Michael, Athan Kuliopulos, Lidija Covic · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
4. Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets
   Summer E. Young, Matthew Thomas Duvernay, M. Schulte · 2013 · PLoS ONE
5. Protease-Activated Receptor 4 Uses Anionic Residues To Interact with α-Thrombin in the Absence or Presence of Protease-Activated Receptor 1
   Marvin T. Nieman · 2008 · Biochemistry
6. Proteinase-activated receptors (PARs)—the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1
   Roland Kaufmann, Beate Schulze, Gerd Krause · 2004 · Regulatory Peptides
7. Helix 8 of the M1 Muscarinic Acetylcholine Receptor: Scanning Mutagenesis Delineates a G Protein Recognition Site
   Robert G. Kaye, José W. Saldanha, Zhi-Liang Lu · 2011 · Molecular Pharmacology
8. Proteinases as hormones: targets and mechanisms for proteolytic signaling
   Kristina K. Hansen, Κατερίνα Οικονομοπούλου, Amos Baruch, Rithwik Ramachandran, Paul L. Beck, Eleftherios P. Diamandis, Morley Donald Hollenberg · 2008 · Biological Chemistry
9. Distinct Activity of Peptide Mimetic Intracellular Ligands (Pepducins) for Proteinase‐Activated Receptor‐1 in Multiple Cells/Tissues
   Satoko Kubo, Tsuyoshi Ishiki, Ichiko Doe · 2006 · Annals of the New York Academy of Sciences
10. Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)
    Pierre E. Thibeault, Jordan C LeSarge, D’Arcy Arends · 2019 · Journal of Biological Chemistry
11. Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure–activity, spectroscopic, and computational studies
    Marco A. Ceruso, David F. McComsey, Gregory C. Leo · 1999 · Bioorganic & Medicinal Chemistry
12. Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function
    Rithwik Ramachandran, Koichiro Mihara, Pierre E. Thibeault · 2017 · Molecular Pharmacology
13. Structure and putative signaling mechanism of Protease activated receptor 2 (PAR2) – A promising target for breast cancer
    Kavita Kumari Kakarala, Kaiser Jamil, Vinod Devaraji · 2014 · Journal of Molecular Graphics and Modelling
14. Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition
    Mohammed N. Meah, Jennifer B. Raftis, Simon Wilson, Vidya Perera, Samira J. Merali, Bindu Murthy, J. Gerry Everlof, RONALD S. ARONSON, Joseph M. Luettgen, David Ernest Newby · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
15. Proteinase-Activated Receptor-4 Plays a Major Role in the Recruitment of Neutrophils Induced by Trypsin or Carrageenan during Pleurisy in Mice
    Lindisley Ferreira Gomides, Igor Dimitri Gama Duarte, Raphael Gomes Ferreira, Aline Pérez, Janetti Nogueira Francischi, André Klein · 2012 · Pharmacology
16. Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting
    Isabel Canto, JoAnn Trejo · 2013 · Journal of Biological Chemistry
17. Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists
    James C. Barrow, Philippe G. Nantermet, Harold G. Selnick et al. · 2001 · Bioorganic & Medicinal Chemistry Letters
18. Potent Small Agonists of Protease Activated Receptor 2
    Mei‐Kwan Yau, Jacky Yung Suen, Weijun Xu · 2015 · ACS Medicinal Chemistry Letters
19. A refined agonist pharmacophore for protease activated receptor 2
    Grant D. Barry, Jacky Yung Suen, Heng Boon Low, Bernhard Pfeiffer, Bernadine M. Flanagan, Maria A. Halili, Giang Thanh Le, David P. Fairlie · 2007 · Bioorganic & Medicinal Chemistry Letters
20. Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling
    Pierre E. Thibeault, Rithwik Ramachandran · 2020 · ACS Pharmacology & Translational Science
21. The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury
    Jih‐Hwa Guh, Yi-Nan Liu, Ya‐Ling Chang · 2004 · Thrombosis and Haemostasis
22. The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability
    Disha M. Gandhi, Ricardo Rosas, Eric Greve et al. · 2019 · Bioorganic & Medicinal Chemistry
23. The human thrombin receptor and proteinase activated receptor‐2 genes are tightly linked on chromosome 5q13
    Valentina A. Schmidt, William C. Nierman, Tamara V. Feldblyum · 1997 · British Journal of Haematology
24. Interruption of the Ionic Lock in the Bradykinin B2 Receptor Results in Constitutive Internalization and Turns Several Antagonists into Strong Agonists
    Jasmin Leschner, Goeran Wennerberg, Jens Feierler, Marcel Bermúdez, Benjamin Welte, Irina Kalatskaya, Gerhard Wolber, Alexander Faußner · 2012 · Journal of Pharmacology and Experimental Therapeutics
25. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators
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26. Characterization of a new peptide agonist of the protease-activated receptor-1
    Yingying Mao, Jianguo Jin, Satya P. Kunapuli · 2007 · Biochemical Pharmacology
27. Discovery of Novel Nonpeptidic PAR2 Ligands
    Ilona Klösel, Maximilian F. Schmidt, Jonas M. Kaindl · 2020 · ACS Medicinal Chemistry Letters
28. Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors
    2013 · Progress in molecular biology and translational science
29. Hepta and octapeptide agonists of protease‐activated receptor 2
    Mark G. Devlin, Bernhard Pfeiffer, Bernadine M. Flanagan, Renée L. Beyer, Thomas M. Cocks, David P. Fairlie · 2007 · Journal of Peptide Science
30. Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization
    Alejandro Álvarez-Arce, Irene Lee-Rivera, Edith López · 2017 · International Journal of Cell Biology
31. Modulation of PAR1signalling by benzimidazole compounds
    Sabrina Asteriti, Simona Daniele, Francesca Porchia et al. · 2012 · British Journal of Pharmacology
32. High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2)
    Jordan C LeSarge, Pierre E. Thibeault, Mark Milne · 2019 · ACS Medicinal Chemistry Letters
33. Regulating protease activated Receptor 2
    Jacky Yung Suen · 2008 · The University of Queensland
34. 3P-0836 Biological characterization of ER129614-06, a novel, non-peptide protease-activated receptor-1 (PAR-1) antagonist
    Motoji Kogushi, Tomomi Matsuoka, Hirokazu Kobayashi · 2003 · Atherosclerosis Supplements
35. Proangiogenic TF-FVIIa-PAR2 Signaling Requires Matriptase-Independent Integrin Interaction
    Andrea S. Rothmeier, Jennifer Disse, Barbara M. Mueller · 2016 · Blood
36. Protease‐Activated Receptor 2
    Qihai Gu, Lu‐Yuan Lee · 2012
37. Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids
    Arundhasa Chandrabalan, Andrew Firth, Robert B. Litchfield, C. Thomas Appleton, Alan M. J. Getgood, Rithwik Ramachandran · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
38. Modulation of PAR1 signaling by benzimidazole compounds
    Isabella Pugliesi, Elisabetta Barresi, Sabrina Taliani · 2012 · CINECA IRIS Institutial research information system (University of Pisa)