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Cited by 15Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Over‐expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice

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Shang, Yingchun, Yan, Yuxing, Chen, Bin, Zhang, Jianhai, Zhang, Tao·2020·Genes, Brain and Behavior
DOI 10.1111/gbb.12678
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Abstract

The activated mammalian Ste20-like serine/threonine kinases 1 (MST1) was found in the central nervous system diseases, such as cerebral ischemia, stroke and ALS, which were related with cognitions. The aim of this study was to examine the effect of elevated MST1 on memory functions in C57BL/6J mice. We also explored the underlying mechanism about the pattern alteration of neural oscillations, closely associated with cognitive dysfunctions, at different physiological rhythms, which were related to a wide range of basic and higher-level cognitive activities. A mouse model of the adeno-associated virus (AAV)-mediated overexpression of MST1 was established. The behavioral experiments showed that spatial memory was significantly damaged in MST1 mice. The distribution of either theta or gamma power was clearly disturbed in MST1 animals. Moreover, the synchronization in both theta and gamma rhythms, and theta-gamma cross-frequency coupling were significantly weakened in MST1 mice. In addition, the expressions of GABAA receptor, GAD67 and parvalbumin (PV) were obviously increased in MST1 mice. Meanwhile, blocking MST1 activity could inhibit the activation of FOXO3a and YAP. The above data suggest that MST1-overexpression may induce memory impairments via disturbing the patterns of neural activities, which is possibly associated with the abnormal GABAergic expression level.

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  • Mst1 overexpression disturbs hippocampal connectivity by increasing GABAergic tone and impairs spatial memory.

    “Mst1 overexpression disturbs hippocampal connectivity by increasing GABAergic tone and impairs spatial memory (Shang et al. 2020)”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Shang et al. 2020

    Section 4.2 reports less effective communication between hippocampal PP and DG regions after MST1 overexpression, and section 3.6 reports impaired spatial memory. The GABAergic-tone discussion reports increased GABAergic markers but says enhanced tone is suggested to be involved in the altered oscillations; it does not establish that increased tone causes the connectivity disturbance. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Shang, Y., Yan, Y., Chen, B., Zhang, J., & Zhang, T.
Affiliations
  • Nankai University (CN)
  • Hangzhou Dianzi University (CN)
Corresponding author
  • Zhang, Jianhai
  • Zhang, Tao
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2020-06-29
Volume
19
Issue
6
Pages
e12678-e12678
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
DOI
10.1111/gbb.12678
OpenAlex
W3030543832
Cited by
15
References
0
Citations by year
2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3
FWCI
1.21
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (31771148, 61633010)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
MST1, spatial memory, neural oscillations, theta oscillations, gamma oscillations, GABAergic inhibition, GABAA receptor, GAD67, parvalbumin, FOXO3, YAP, cognitive impairment
MeSH terms
Forkhead Box Protein O3, YAP-Signaling Proteins, Hippo Kinases, Animals, Brain, Cognition, Glutamate Decarboxylase, Male, Mice, Inbred C57BL, Parvalbumins, Receptors, GABA-A, Theta Rhythm, Up-Regulation, Protein Serine-Threonine Kinases, Adaptor Proteins, Signal Transducing, Mice, Gamma Rhythm, Spatial Memory

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