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Cited by 39Osteoarthritis Treatment and MechanismsRheumatoid Arthritis Research and TherapiesHemophilia Treatment and Research

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Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: The role of angiogenesis

Open access
Caliogna, Laura, Berni, Micaela, Torriani, Camilla, Mancuso, Maria Elisa, Di Minno, Matteo Nicola Dario, Brancato, Alice Maria, Jannelli, Eugenio, Mosconi, Mario, Pasta, Gianluigi·2024·Haemophilia
DOI 10.1111/hae.15097PMC PMC11659485
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Abstract

Introduction: The term ‘chronic inflammatory arthritis’ (IA) can be used to define a group of heterogeneous diseases in which inflammation of the synovium is the common feature while having different pathogenesis and clinical outcomes. This condition can be found in osteoarthritis (OA), rheumatoid arthritis (RA), and hemophilic arthropathy (HA). Aim: The objective is to try to highlight similarities and differences in the three pathological conditions and understand both molecular and physiological mechanisms. Method: We have carried out a systematic review of the available literature following the guidelines Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA). Results: By comparing the data in the literature on OA, RA, and HA we have shown that the three pathologies differ in initial etiology but they motivate the same molecular pathways. Conclusion: In this review we highlighted the similarities and differences between these diseases, creating ideas for future studies both in vivo and in vitro to develop new therapeutic agents and suggest possible biomarkers to follow the evolution and severity of the disease.

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Crossref · 10.1111/hae.15097

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FIGURE 1 PRISMA 2020 flow diagram for new systematic reviews which included searches of databases, registers and other sources. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta‐analysis.
FIGURE 1 PRISMA 2020 flow diagram for new systematic reviews which included searches of databases, registers and other sources. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta‐analysis.CC BY-NC · PubMed Central
FIGURE 2 Molecular mechanism involves in OA, RA, and HA pathogenesis. The image shows the pathways activated during OA, RA, and HA pathogenesis and the principal effects of these pathology at level of articulation. ANG‐1, angiopoietins 1; EC, endothelial cells; HA, hemophilic arthropathy; HIF, hypoxia‐inducible factor; IL‐1ß, cytokine interleukin‐1β; IL‐6, cytokine interleukin‐6; M1, macrophages involved in host defence; MMPs, matrix metalloproteinase; OA, osteoarthritis; RA, rheumatoid arthritis; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.
FIGURE 2 Molecular mechanism involves in OA, RA, and HA pathogenesis. The image shows the pathways activated during OA, RA, and HA pathogenesis and the principal effects of these pathology at level of articulation. ANG‐1, angiopoietins 1; EC, endothelial cells; HA, hemophilic arthropathy; HIF, hypoxia‐inducible factor; IL‐1ß, cytokine interleukin‐1β; IL‐6, cytokine interleukin‐6; M1, macrophages involved in host defence; MMPs, matrix metalloproteinase; OA, osteoarthritis; RA, rheumatoid arthritis; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.CC BY-NC · PubMed Central
FIGURE 3 Role of angiogenesis in pathogenesis of OA, RA, and HA. The image shows the pathways activated by angiogenesis in OA, RA, and HA and the principal effects. HA, hemophilic arthropathy; HIF, hypoxia‐inducible factor; MMPs, matrix metalloproteinase; PKC‐δ, protein kinase C δ; SMA‐α, α‐smooth muscle actin; ß‐NGF, nerve growth factor; OA, osteoarthritis; RA, rheumatoid arthritis; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.
FIGURE 3 Role of angiogenesis in pathogenesis of OA, RA, and HA. The image shows the pathways activated by angiogenesis in OA, RA, and HA and the principal effects. HA, hemophilic arthropathy; HIF, hypoxia‐inducible factor; MMPs, matrix metalloproteinase; PKC‐δ, protein kinase C δ; SMA‐α, α‐smooth muscle actin; ß‐NGF, nerve growth factor; OA, osteoarthritis; RA, rheumatoid arthritis; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.CC BY-NC · PubMed Central
FIGURE 4 Therapeutic treatment of OA, RA, and HA. For each chronic inflammatory arthritis, the current therapeutic treatments are shown in green and the treatments are still under study in fuchsia. The treatments under study for RA involve an amplification of those already existing (shown in yellow). ANG‐1, angiopoietins 1; EC, endothelial cells; HIF, hypoxia‐inducible factor; IL‐1ß, cytokine interleukin‐1β; IL‐6, cytokine interleukin‐6; M1, macrophages involved in host defence; MMPs, matrix metalloproteinase; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.
FIGURE 4 Therapeutic treatment of OA, RA, and HA. For each chronic inflammatory arthritis, the current therapeutic treatments are shown in green and the treatments are still under study in fuchsia. The treatments under study for RA involve an amplification of those already existing (shown in yellow). ANG‐1, angiopoietins 1; EC, endothelial cells; HIF, hypoxia‐inducible factor; IL‐1ß, cytokine interleukin‐1β; IL‐6, cytokine interleukin‐6; M1, macrophages involved in host defence; MMPs, matrix metalloproteinase; TNF‐α, tumour necrosis factor; VEGF, vascular endothelial growth factor.CC BY-NC · PubMed Central

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Citations

Cites

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Metadata

Authors
Caliogna, L., Berni, M., Torriani, C., Mancuso, M. E., Di Minno, M. N. D., Brancato, A. M., Jannelli, E., Mosconi, M., & Pasta, G.
Affiliations
  • Policlinico San Matteo Fondazione (IT)
  • IRCCS Humanitas Research Hospital (IT)
  • Department of Translational Medical Sciences Federico II University Napoli Italy
  • University of Pavia (IT)
Corresponding author
Pasta, Gianluigi
ORCID
Venue
Haemophilia
Publisher
Wiley
Published
2024-09-19
Volume
30
Issue
6
Pages
1256-1264
ISSN
  • 1351-8216 (ISSN-L)
  • 1365-2516
DOI
10.1111/hae.15097
PMC
PMC11659485
OpenAlex
W4402619639
Cited by
39
References
1
Citations by year
2026: 26 · 2025: 13
FWCI
12.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Haemophilia (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Hematology › Hemophilia Treatment and Research
Keywords
osteoarthritis, rheumatoid arthritis, hemophilic arthropathy, angiogenesis, chronic inflammatory arthritis, synovitis, pathogenesis, molecular pathways, biomarkers, therapeutic target
MeSH terms
Angiogenesis, Arthritis, Rheumatoid, Hemarthrosis, Hemophilia A, Humans, Neovascularization, Pathologic, Osteoarthritis

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