The G lycemic I ndices in D ialysis E valuation (GIDE) study: Comparative measures of glycemic control in diabetic dialysis patients
Abstract
The validity of hemoglobin A1c (HgbA1c) is undergoing increasing scrutiny in the advanced CKD/ESRD (chronic kidney disease/end-stage renal disease) population, where it appears to be discordant from other glycemic indices. In the Glycemic Indices in Dialysis Evaluation (GIDE) Study, we sought to assess correlation of HgbA1c with casual glucose, glycated albumin, and serum fructosamine in a large group of diabetic patients on dialysis. From 26 dialysis facilities in the United States, 1758 diabetic patients (hemodialysis = 1476, peritoneal dialysis = 282) were enrolled in the first quarter of 2013. The distributions of HgbA1c and the other glycemic indices were analyzed. Intra-patient coefficients of variation and correlations among the four glycemic indices were determined. Patients with low HgbA1c values were both on higher erythropoietin (ESA) doses and more anemic. Serum glucose exhibited the highest intra-patient variability over a 3-month period; variability was modest among the other glycemic indices, and least with HgbA1c. Statistical analyses inclusive of all glycemic markers indicated modest to strong correlations. HgbA1c was more likely to be in the target range than glycated albumin or serum fructosamine, suggesting factors which may or may not be directly related to glycemic control, including anemia, ESA management, and iron administration, in interpreting HgbA1c values. These initial results from the GIDE Study clarify laboratory correlations among glycemic indi…
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Correlations of fructosamine with HbA1c and mean blood glucose were examined in 4 observational studies.
“Correlations of fructosamine with HbA1c and mean blood glucose were examined in 4 observational studies.”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [200]
Cites
Comparison of glycated albumin and hemoglobin A1c levels in diabetic subjects on hemodialysis
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KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease
de Boer, I. H., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.06.019 · Cited by 1,399 · see citing works
KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Rossing, P., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.008 · Cited by 1,373 · see citing works
- Authors
- Williams, M. E., Mittman, N., Ma, L., Brennan, J. I., Mooney, A., Johnson, C. D., Jani, C. M., Maddux, F. W., & Lacson, E.
- Affiliations
- Joslin Diabetes Center (US)
- Department of Dialysis Kidney Care of Brooklyn and Queens Brooklyn New York USA
- Fresenius Medical Care (United States) (US)
- Department of Research Spectra Laboratories Rockleigh New Jersey USA
- Corresponding author
- Williams, Mark E.
- Venue
- Hemodialysis International
- Publisher
- Wiley
- Published
- 2015-05-12
- Volume
- 19
- Issue
- 4
- Pages
- 562-571
- ISSN
- 1492-7535 (ISSN-L)
- 1542-4758
- OpenAlex
- W2139255580
- Cited by
- 30
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hemodialysis International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- glycemic control, HbA1c, glycated albumin, serum fructosamine, diabetes mellitus, dialysis, end-stage renal disease, chronic kidney disease, anemia, erythropoietin, iron therapy, intrapatient variability
- MeSH terms
- Aged, Blood Glucose, Diabetes Mellitus, Female, Renal Dialysis, Glycated Hemoglobin, Humans, Kidney Failure, Chronic, Male, Middle Aged, Cohort Studies, Glycemic Index
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