Region-Wise Distribution of High-Risk Human Papillomavirus Types in Squamous Cell Carcinomas of the Cervix in India
Open accessAbstract
Hypothesis Assessment of the prevalence and type distribution of human papillomavirus (HPV) in squamous cell carcinomas (SCC) of the cervix across India was undertaken to estimate the impact of available prophylactic HPV-L1 vaccines in the country and to find out additional types that might be needed to be incorporated in second-generation vaccines. Methods High-risk (HR) HPVs were genotyped from 667 histopathologically confirmed cases of SCC from 6 different centers representing 4 regions across India: Advanced Centre for Treatment, Research and Education in Cancer, Mumbai; All India Institute of Medical Sciences, New Delhi; Cancer Foundation of India, Kolkata; Christian Medical College, Vellore; Kidwai Memorial Institute of Oncology, Bangalore; and Regional Cancer Center, Thiruvananthapuram. Human papillomaviruses in tumor biopsies were analyzed by Xcytonscreen HPV based on PGMY09/11 multiplex polymerase chain reaction and reverse dot blot assay. Results Overall viral prevalence across India was not different; 92.1% of 667 cases harbored HPV; 8% were negative. Infection with single HR type was seen in 86.8%: predominant types being HPV-16 followed by HPV-18, -45, -73, -31, -56, -52, -58, -59, -33, -68, -51, -35, -26, and -39. Human papillomavirus types 16/18-positive fraction formed 79.6%; other types comprised 12.4%. Conclusions Prophylactic HPV-16/18-L1 vaccines would provide greater than 75% protection against SCC in India. Ranking and frequencies of non-16/18 types were…
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In Kolkata, 59-74% of ICC cases are infected with HPV 16 and 2-13.9% with HPV 18.
“In Kolkata, 59–74% of ICC cases are infected with HPV 16 and 2–13.9% cases infected with HPV 18 [7, 18].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [18]
The genotype distribution in ICC cases is quite similar to studies reported from India and worldwide.
“Analysis of genotypes distribution in ICC cases showed that HPV 16(83.78%) and 18(21.08%) were the most predominant genotypes which is quite similar to the studies reported from India and worldwide.”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [18]
Reports from south India showed HPV 16 and HPV18 account for 58-69% and 5-19.4% of ICC cases respectively.
“Reports from south India showed HPV 16 and HPV18 accounts for 58–69% and 5–19.4% of ICC cases respectively [16, 18].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [18]
Other parts of Central and west India have similar reports showing HPV 16 (72-73.6%) as the most predominant genotype followed by HPV18 (5-11.9%) in cervical carcinoma cases.
“Other parts of Central and west India also have similar reports showing HPV 16(72–73.6%) as the most predominant genotype followed by HPV18 (5–11.9%) in cervical carcinoma cases [18, 20].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [18]
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Senapati, R., Nayak, B., Kar, S. K., & Dwibedi, B. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-016-2136-4 · Cited by 95 · see citing works
- Authors
- Pillai, R. M., Babu, J. M., Jissa, V. T., Lakshmi, S., Chiplunkar, S. V., Patkar, M., Tongaonkar, H., Reddy, K. B., Chakka, K. N., Siddiqui, M., Roychoudury, S., Abraham, P., Peedicayil, A., Gnanamony, M., Subashini, J., Ram, T. S., Dey, B., Singh, N., Singh, A., Jain, S. K., & Jayshree, R. S.
- Affiliations
- Rajiv Gandhi Centre for Biotechnology (IN)
- Regional Cancer Center, Thiruvananthapuram (IN)
- Tata Memorial Hospital (IN)
- Kidwai Memorial Institute of Oncology (IN)
- Cancer Foundation of India (IN)
- Christian Medical College, Vellore (IN)
- Department of Biotechnology (IN)
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Jayshree, R.S.
- ORCID
- Venue
- International Journal of Gynecological Cancer
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 20
- Issue
- 6
- Pages
- 1046-1051
- ISSN
- 1048-891X (ISSN-L)
- OpenAlex
- W2069648860
- Cited by
- 28
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- International Journal of Gynecological Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Surgery › Genital Health and Disease
- Keywords
- high-risk HPV, cervical squamous cell carcinoma, HPV genotype distribution, HPV16, HPV 18, HPV45, HPV52, HPV58, HPV 59, HPV 31, HPV 33, HPV68, HPV35, HPV39, HPV51, HPV 56, HPV53, HPV 66, HPV 69, HPV70, HPV73, HPV81, HPV 82, HPV 83, HPV84
- MeSH terms
- Adult, Aged, Aged, 80 and over, Biopsy, Needle, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, DNA, Viral, Female, Humans, Immunohistochemistry, India, Middle Aged, Precancerous Conditions, Vaginal Smears, Cohort Studies, Prevalence, Polymerase Chain Reaction, Age Distribution, Risk Assessment, Papillomaviridae, Papillomavirus Infections, Human papillomavirus 18, Human papillomavirus 16, Papillomavirus Vaccines
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