Inhibition of MicroRNA‐21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis

Background Prolonged activation of dermal fibroblasts is the main cause of progressive fibrosis in systemic sclerosis ( SSc ). It seems that inhibition of apoptosis in SSc fibroblasts deregulates fibrosis. Micro RNA ‐21 (miR‐21) is a pro‐fibrotic factor with high expression in lesional areas of S…