Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood
Open accessAbstract
Summary: Background: Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown. Methods: Among 1418 children in Project Viva, a Boston‐area pre‐birth cohort, we assessed anthropometric and biochemical parameters of cardiometabolic health in early (median age 3.3 years) and mid‐ (median age 7.7 years) childhood. We used spatiotemporal models to estimate prenatal and early life residential PM 2.5 and black carbon exposure as well as traffic density and roadway proximity. We performed linear regression analyses adjusted for sociodemographics. Results: Children whose mothers lived close to a major roadway at the time of delivery had higher markers of adverse cardiometabolic risk in early and mid‐childhood. For example, total fat mass was 2.1 kg (95%CI: 0.8, 3.5) higher in mid‐childhood for children of mothers who lived <50 m vs. ≥200 m from a major roadway. Black carbon exposure and traffic density were generally not associated with cardiometabolic parameters, and PM 2.5 exposure during the year prior was paradoxically associated with improved cardiometabolic profile. Conclusions: Infants whose mothers lived close to a major roadway at the time of delivery may be at later risk for adverse cardiometabolic health.
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Children who lived close to a highway during delivery were found to have increased adipose tissue accumulation during early and mid-childhood.
“The same investigators followed a cohort of 1400 children that lived close to a highway during delivery. Children were found to have increased adipose tissue accumulation during early and mid-childhood [37].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [37]
The Methods report a cohort of 1,418 children, but the Results (Population characteristics) say only 3% of mothers lived within 50 m of a major roadway at delivery—not that all 1,400 children lived close to one. The Discussion reports greater adiposity in early and mid-childhood among children whose mothers lived close to a major roadway at delivery. Page numbers are unavailable in our copy. (LLM, conf=0.91)
Experimental — accuracy not yet measuredParadoxically, PM2.5 exposure improved cardiometabolic markers.
“Paradoxically, PM2.5 exposure improved cardiometabolic markers.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [37]
The Results (Air pollution exposure and mid-childhood cardiometabolic risk; page not provided) report that PM2.5 exposure in the preceding year was associated, contrary to the authors’ hypothesis, with lower BMI z-score, fat mass, and HOMA-IR. But “improved” implies an effect that the observational association does not establish, and the Discussion says the associations were sporadic and did not follow a clear pattern. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Cites
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Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“Children were found to have increased adipose tissue accumulation during early and mid-childhood [37].”
BackgroundEnvironmental pollution and the risk of developing metabolic disorders: obesity and diabetes
Khalil, W. J., Akeblersane, M., Khan, A. S., Moin, A. S. M., & Butler, A. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108870 · Cited by 95 · see citing works
- Authors
- Fleisch, A. F., Luttmann‐Gibson, H., Perng, W., Rifas‐Shiman, S. L., Coull, B. A., Kloog, I., Koutrakis, P., Schwartz, J. D., Zanobetti, A., Mantzoros, C. S., Gillman, M. W., Gold, D. R., & Oken, E.
- Affiliations
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Michigan (US)
- Ben-Gurion University of the Negev (IL)
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Fleisch, A. F.
- ORCID
- Venue
- Pediatric Obesity
- Publisher
- Wiley
- Published
- 2016-02-04
- Volume
- 12
- Issue
- 1
- Pages
- 48-57
- ISSN
- 2047-6302 (ISSN-L)
- 2047-6310
- PMC
- PMC4974151
- OpenAlex
- W2256574973
- Cited by
- 84
- References
- 1
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 3
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (K24HD069408, R37HD034568, P30DK092924, P30ES000002, P01ES009825, R01AI102960, K12DK094721, K23ES024803)
- Environmental Protection Agency (RD83479801\)
- Harvard School of Public Health
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Social Sciences › Transportation › Urban Transport and Accessibility
- Keywords
- traffic-related air pollution, prenatal exposure, early childhood, cardiometabolic health, PM2.5, black carbon, traffic density, childhood obesity, fat mass, infant weight gain, Project Viva cohort
- MeSH terms
- Air Pollutants, Air Pollution, Boston, Child, Child, Preschool, Environmental Exposure, Female, Humans, Infant, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Regression Analysis, Cohort Studies, Biomarkers, Metabolic Syndrome
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