Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight
Open accessAbstract
Summary: Objective: Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain. Methods: The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months). Results: A one standard deviation (1‐SD: 2 ppb) increase in prenatal non‐freeway nitrogen oxides was associated with 33% ( P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels ( P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways ( P = 0.03). A 1‐SD (10 ng mL −1 ) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48). Conclusions: Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.
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Alderete et al. demonstrated that prenatal residential traffic-related air pollution exposure was associated with higher adipokines, leptin, and adiponectin levels in umbilical cord blood.
“Alderete et al. [34] demonstrated that prenatal residential traffic-related air pollution exposure was associated with higher adipokines, leptin, and adiponectin levels in umbilical cord blood.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [34]
Increased leptin levels correlated with significant weight gain in female infants, which investigators reasoned could increase future obesity risk.
“Increased leptin levels correlated with significant weight gain in female infants, which investigators reasoned could increase future obesity risk.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [34]
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Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“[34] demonstrated that prenatal residential traffic-related air pollution exposure was associated with higher adipokines, leptin, and adiponectin levels in umbilical cord blood.”
Background
- Authors
- Alderete, T. L., Song, A. Y., Bastain, T., Habre, R., Toledo‐Corral, C. M., Salam, M. T., Lurmann, F., Gilliland, F. D., & Breton, C. V.
- Affiliations
- University of Southern California (US)
- California State University Los Angeles (US)
- Sonoma Technology (United States) (US)
- Corresponding author
- Breton, C. V.
- ORCID
- Venue
- Pediatric Obesity
- Publisher
- Wiley
- Published
- 2017-11-03
- Volume
- 13
- Issue
- 6
- Pages
- 348-356
- ISSN
- 2047-6302 (ISSN-L)
- 2047-6310
- PMC
- PMC5934325
- OpenAlex
- W2766544020
- Cited by
- 47
- References
- 1
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (K99ES027853, P30ES007048, R01ES021801, R21ES025870)
- Environmental Protection Agency (83615801‐0)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- traffic-related air pollution, prenatal exposure, leptin, adiponectin, infant weight gain, childhood obesity, nitrogen oxides, sex differences, birth cohort
- MeSH terms
- Traffic-Related Pollution, Adult, Air Pollutants, Air Pollution, Body Weight, California, Child, Female, Fetal Blood, Humans, Infant, Infant, Newborn, Male, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Weight Gain, Linear Models, Adipokines, Pediatric Obesity
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