The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis
Abstract
Summary: By virtue of their position at the crossroads between the innate and adaptive immune response, macrophages play an essential role in the control of bacterial infections. Paradoxically, macrophages serve as the natural habitat to Mycobacterium tuberculosis (Mtb). Mtb subverts the macrophage's mechanisms of intracellular killing and antigen presentation, leading ultimately to the development of tuberculosis (TB) disease. Here, we describe mechanisms of Mtb uptake by the macrophage and address key macrophage functions that are targeted by Mtb‐specific effector molecules enabling this pathogen to circumvent host immune response. The macrophage functions described in this review include fusion between phagosomes and lysosomes, production of reactive oxygen and nitrogen species, antigen presentation and major histocompatibility complex class II expression and trafficking, as well as autophagy and apoptosis. All these are Mtb‐targeted key cellular pathways, normally working in concert in the macrophage to recognize, respond, and activate ‘proper’ immune responses. We further analyze and discuss major molecular interactions between Mtb virulence factors and key macrophage proteins and provide implications for vaccine and drug development.
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Cites
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Cited by
Innate immunity in tuberculosis: host defense vs pathogen evasion
Liu, C. H., Liu, H., & Ge, B. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2017.88 · Cited by 532
Quigley, J., Hughitt, V. K., Velikovsky, C. A., Mariuzza, R. A., El-Sayed, N. M., & Briken, V. (2017) · mBio · doi:10.1128/mbio.00148-17 · Cited by 234
Metadata
- Authors
- Hmama, Z., Peña‐Díaz, S., Joseph, S., & Av‐Gay, Y.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-02-20
- Volume
- 264
- Issue
- 1
- Pages
- 220-232
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2011089730
- Cited by
- 290
- References
- 135
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hmama, Z., Peña‐Díaz, S., Joseph, S., & Av‐Gay, Y. (2015). Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis. Immunological Reviews. https://doi.org/10.1111/imr.12268
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
