Electrolyte therapy for refractory seizures in familial dysautonomia
Abstract
Purpose Video-EEG in a family of three patients with slow development and familial dysautonomia demonstrated absence seizures associated with 3-Hz generalized spike-and-wave discharges. The seizures were refractory to antiepileptic drugs (AEDs). Methods Treatment was given with rice-based cereal electrolyte oral solution. Results Treatment induced seizure freedom and normalization of EEG in all three patients. Repeated video-EEG monitoring with discontinuation of AEDs and maintenance of the oral hydration therapy was associated with recurrence of epileptic activity. All three patients have remained seizure free (approximately 1 year) with a combination of topiramate and electrolytic therapy. Conclusions Rice-based oral electrolyte hydration therapy may play a role in prevention and control of seizures in patients with familial dysautonomia.
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Hyperosmolar states decrease susceptibility to epileptic seizures.
“Hyperosmolar states decrease and hyposmolar states increase the susceptibility to epileptic seizures (Osehobo & Andrew, 1993;Ochoa, 2004)”
From Significance of SGK1 in the regulation of neuronal function (2010) · cites this paper as Ochoa, 2004
Hyposmolar states increase susceptibility to epileptic seizures.
“Hyperosmolar states decrease and hyposmolar states increase the susceptibility to epileptic seizures (Osehobo & Andrew, 1993;Ochoa, 2004)”
From Significance of SGK1 in the regulation of neuronal function (2010) · cites this paper as Ochoa, 2004
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Significance of SGK1 in the regulation of neuronal function
Lang, F., Strutz-Seebohm, N., Seebohm, G., & Lang, U. E. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190926 · Cited by 170 · see citing works
- Authors
- Ochoa, J. G.
- Affiliations
- University of Florida (US)
- Corresponding author
- Ochoa, Juan G.
- ORCID
- Ochoa, Juan G.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2004-10-27
- Volume
- 45
- Issue
- 11
- Pages
- 1461-1462
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1978184463
- Cited by
- 6
- References
- 0
- Citations by year
- 2017: 1 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Keywords
- familial dysautonomia, refractory seizures, absence seizures, electrolyte therapy, generalized spike-wave discharges, topiramate, antiepileptic drug discontinuation, seizure recurrence
- MeSH terms
- Anticonvulsants, Carbohydrates, Citrates, Dysautonomia, Familial, Electrolytes, Epilepsy, Humans, Potassium, Oryza, Sodium, Rehydration Solutions, Comorbidity, Treatment Outcome
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