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Cited by 22Hair Growth and DisordersSkin and Cellular Biology Researchmelanin and skin pigmentation

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Progressive Hair Loss and Myocardial Degeneration in Rough Coat Mice: Reduced Lysyl Oxidase-Like (LOXL) in the Skin and Heart

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Hayashi, Kimiko, Cao, Tongyu, Passmore, Howard, Saux, Claude Jourdan-Le, Fogelgren, Ben, Khan, Subarna, Hornstra, Ian, Kim, Youngho, Hayashi, Masando, Csiszar, Katalin·2004·Journal of Investigative Dermatology
DOI 10.1111/j.0022-202x.2004.23436.x
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Abstract

The rough coat (rc) is a spontaneous recessive mutation in mice. To identify the mutated gene, we have characterized the rc phenotype and initiated linkage mapping. The rc mice show growth retardation, cyclic and progressive hair loss, hyperplastic epidermis, abnormal hair follicles, cardiac muscle degeneration, and reduced amount of collagen and elastin in the skin and heart. The rc locus was mapped at 32.0 cM on chromosome 9, close to the loxl gene. Lysyl oxidase-like (LOXL) protein is a novel copper-containing amine oxidase that is required for the cross-linking of elastin and collagen in vitro. LOXL is expressed at high levels in the skin and heart, where the rc mice show strong phenotype. The expression pattern and the genetic proximity to rc suggested loxl as a potential candidate gene. In rc mice, the loxl mRNA was reduced in the skin and the LOXL protein in the heart, dermis, atrophic hair follicles, and sebaceous glands. No mutations, however, were identified within the coding region of loxl, and offspring from rc/rc and loxl null mice crossing were phenotypically normal. Based on these results, loxl appears non-allelic to rc. Heart- and skin-specific downregulation of LOXL in rc mice, however, may contribute to the extracellular matrix alterations and the rc phenotype.

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Research works printed but not linked: 37

  1. Ahmad, 1999, The molecular basis of congenital atrichia in humans and mice: Mutations in the hairless gene, J Investig Dermatol Symp Proc, 4, 240, 10.1038/sj.jidsp.5640220 · DOI
  2. Bazzano, 1993, Effect of retinoids on follicular cells, J Invest Dermatol, 101, 138S, 10.1111/1523-1747.ep12363264 · DOI
  3. Benavides, 1999, Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency, Immunogenetics, 49, 413, 10.1007/s002510050514 · DOI
  4. Borel, 2001, Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1, J Biol Chem, 276, 48944, 10.1074/jbc.M109499200 · DOI
  5. Bradshaw, 2003, SPARC-null mice exhibit increased adiposity without significant differences in overall body weight, Proc Natl Acad Sci USA, 100, 6045, 10.1073/pnas.1030790100 · DOI
  6. Csiszar, 2001, Lysyl oxidases: A novel multifunctional amine oxidase family, Prog Nucleic Acid Res Mol Biol, 70, 1, 10.1016/S0079-6603(01)70012-8 · DOI
  7. Das, 1995, Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse, Am J Hum Genet, 56, 570
  8. Decitre, 1998, Lysyl oxidase-like protein localizes to sites of de novo fibrinogenesis in fibrosis and in the early stromal reaction of ductal breast carcinomas, Lab Invest, 78, 143
  9. Dickie, 1966, Rough coat, Mouse News Lett, 34, 30
  10. Eicher, 1977, Rough coat on chromosome 9, Mouse News Lett, 56, 42
  11. Flanagan, 1966, “Nude”, a new hairless gene with pleiotropic effects in the mouse, Genet Res, 8, 295, 10.1017/S0016672300010168 · DOI
  12. Gershwin, 1977, DiGeorge syndrome: Congenital thymic hypoplasia. Animal model: congenitally athymic (nude) mouse, Am J Pathol, 89, 809
  13. Grimes, 1997, Molecular basis of the brindled mouse mutant (Mo(br)): A murine model of Menkes disease, Hum Mol Genet, 6, 1037, 10.1093/hmg/6.7.1037 · DOI
  14. Hayashi, 1987, Immunocytochemistry of cell surface heparan sulfate proteoglycan in mouse tissues. A light and electron microscopic study, J Histochem Cytochem, 35, 1079, 10.1177/35.10.2957423 · DOI
  15. Heiniger, 1974, Hereditary immunodeficiency and leukemogenesis in HRS-J mice, Cancer Res, 34, 201
  16. Hornstra, 2003, Lysyl oxidase is required for vascular and diaphragmatic development in mice, J Biol Chem, 278, 14387, 10.1074/jbc.M210144200 · DOI
  17. Kagan, 2000, Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis, Acta Trop, 77, 147, 10.1016/S0001-706X(00)00128-5 · DOI
  18. Kagan, 1979, Purification and properties of four species of lysyl oxidase from bovine aorta, Biochem J, 177, 203, 10.1042/bj1770203 · DOI
  19. Kenyon, 1993, A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24–q25, J Biol Chem, 268, 18435, 10.1016/S0021-9258(17)46643-9 · DOI
  20. Kim, 1995, A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase, J Biol Chem, 270, 7176, 10.1074/jbc.270.13.7176 · DOI
  21. Kim, 1999, Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis, J Cell Biochem, 72, 181, 10.1002/(SICI)1097-4644(19990201)72:2<181::AID-JCB3>3.0.CO;2-D · DOI
  22. Kohara, 2001, A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9, Immunogenetics, 53, 15, 10.1007/s002510000286 · DOI
  23. Levinson, 1997, Deletion of the promoter region in the Atp7a gene of the mottled dappled mouse, Nat Genet, 16, 224, 10.1038/ng0797-224 · DOI
  24. Li, 1997, Localization and activity of lysyl oxidase within nuclei of fibrogenic cells, Proc Natl Acad Sci USA, 94, 12817, 10.1073/pnas.94.24.12817 · DOI
  25. Liu, 2004, Elastic fiber homeostasis requires lysyl oxidase-like 1 protein, Nat. Genet, 36, 178, 10.1038/ng1297 · DOI · Paper page
  26. Mercer, 1994, Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice, Nat Genet, 6, 374, 10.1038/ng0494-374 · DOI
  27. Palamakumbura, 2002, A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples, Anal Biochem, 300, 245, 10.1006/abio.2001.5464 · DOI
  28. Reed, 1997, Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease, Hum Mol Genet, 6, 417, 10.1093/hmg/6.3.417 · DOI
  29. Reske-Kunz, 1979, Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice, J Exp Med, 149, 228, 10.1084/jem.149.1.228 · DOI
  30. Rufaut, 1999, Identification of differentially expressed genes during a wool follicle growth cycle induced by prolactin, J Invest Dermatol, 113, 865, 10.1046/j.1523-1747.1999.00775.x · DOI
  31. Ruvinsky, 2002, Genetics analysis of mouse mutations Abnormal feet and tail and rough coat, which cause developmental abnormalities and alopecia, Mamm Genome, 13, 675, 10.1007/s00335-002-2191-6 · DOI
  32. Shiraishi, 1993, Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease, Biol Trace Elem Res, 39, 129, 10.1007/BF02783183 · DOI
  33. Sternberger, 1979, The unlabeled antibody method. Hormone receptor, Golgi-like and dual color immunocytochemistry, J Histochem Cytochem, 27, 1658, 10.1177/27.12.230258 · DOI
  34. Tchernev, 1997, Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9, Mamm Genome, 8, 621, 10.1007/s003359900520 · DOI
  35. Vestergaard, 2000, The NC/Nga mouse: A model for atopic dermatitis, Mol Med Today, 6, 209, 10.1016/S1357-4310(00)01683-X · DOI
  36. Vulpe, 1993, Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase, Nat Genet, 3, 7, 10.1038/ng0193-7 · DOI
  37. Wydner, 1997, An intron capture strategy used to identify and map a lysyl oxidase- like gene on chromosome 9 in the mouse, Genomics, 40, 342, 10.1006/geno.1996.4574 · DOI

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Metadata

Authors
Hayashi, K., Cao, T., Passmore, H., Saux, C. J.-L., Fogelgren, B., Khan, S., Hornstra, I., Kim, Y., Hayashi, M., & Csiszar, K.
Affiliations
  • University of Hawaiʻi at Mānoa (US)
  • Rutgers, The State University of New Jersey (US)
  • Barnes-Jewish Hospital (US)
  • Asan Medical Center (KR)
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2004-11
Volume
123
Issue
5
Pages
864-871
ISSN
0022-202X (ISSN-L)
DOI
10.1111/j.0022-202x.2004.23436.x
OpenAlex
W2002447427
Cited by
22
References
0
Citations by year
2023: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ca076580-05)
  • National Cancer Institute (CA76580)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (S11AR047713, AR47713)
  • National Center for Research Resources (RR16453, P20RR016453, RR03061)
Topics
  • Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
hair loss, myocardial degeneration, collagen cross-linking, elastin, extracellular matrix, epidermal hyperplasia, hair follicle, sebaceous glands, linkage mapping, recessive mutations
MeSH terms
Alopecia, Amino Acid Oxidoreductases, Animals, Collagen, Elastin, Epidermis, Female, Immunohistochemistry, Genetic Linkage, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Mutant Strains, Myocardium, Phenotype, RNA, Messenger, Mice

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CoChat. (2026). Citation check: Progressive Hair Loss and Myocardial Degeneration in Rough Coat Mice: Reduced Lysyl Oxidase-Like (LOXL) in the Skin and Heart. https://app.cochat.ai/papers/10.1111/j.0022-202x.2004.23436.x
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Hayashi, K., Cao, T., Passmore, H., Saux, C. J.-L., Fogelgren, B., Khan, S., Hornstra, I., Kim, Y., Hayashi, M., & Csiszar, K. (2004). Progressive Hair Loss and Myocardial Degeneration in Rough Coat Mice: Reduced Lysyl Oxidase-Like (LOXL) in the Skin and Heart. Journal of Investigative Dermatology. https://doi.org/10.1111/j.0022-202x.2004.23436.x

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