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A Novel T Cell Receptor Transgenic Animal Model of Seborrheic Dermatitis-Like Skin Disease
Open accessAbstract
We have characterized a novel animal model of the common inflammatory skin disease seborrheic dermatitis (SD) that involves the expression of the self-specific 2C transgenic T cell receptor on the DBA/2 genetic background. Opportunistic fungal pathogens are present in the primary histological lesions and severe disease can be mitigated by the administration of fluconazole, demonstrating a role for infection in disease pathogenesis. Spontaneous disease convalescence occurs at 70-90 d of age and is preceded by an expansion of CD4+ T cells that partially restores the T cell lymphopenia that occurs in these animals. The adoptive transfer of syngeneic CD4+ T cells into pre-diseased DBA/2 2C mice completely abrogates the development of cutaneous disease. The pattern of disease inheritance in DBA/2 backcrosses suggests that one, or a closely linked group of genes, may control disease penetrance. Bone marrow reconstitution experiments demonstrated that the DBA/2 susceptibility factor(s) governing disease penetrance is likely non-hematopoietic since bone marrow from disease-resistant 2C mice can adoptively transfer the full disease phenotype to non-transgenic DBA/2 animals. This model implicates fungal organisms and CD4+ T cell lymphopenia in the development of a SD-like condition and, as such, may mimic the development of SD in acquired immunodeficiency syndrome.
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These observations support the notion that immune compromise and fungal infection play active roles in SD.
“These observations support the notion that immune compromise and fungal infection play active roles in SD.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [82]
Antifungal treatment reversed clinical and pathology presentations and reduced PAS staining in the transgenic mouse model.
“Furthermore, antifungal treatment reversed clinical and pathology presentations, and reduced PAS staining [82].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [82]
Transgenic mice carrying the 2C T cell receptor (TCR) transgene in the DBA/2 background developed an extremely inflammatory phenotype in seborrheic areas.
“Consistent with a role for altered immunity in the pathogenesis of SD, transgenic mice carrying the 2C T cell receptor (TCR) transgene in the DBA/2 background developed extremely inflammatory phenotype in seborrheic areas, such as the ears, around the eyes, and muzzle area [82].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [82]
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Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
Metadata
- Authors
- Oble, D. A., Collett, E., Hsieh, M., Ambjørn, M., Law, J., Dutz, J., & Teh, H.-S.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Teh, Hung-Sia
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 124
- Issue
- 1
- Pages
- 151-159
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1979064330
- Cited by
- 24
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arthritis Society
- University of Alberta
- Michael Smith Health Research BC
- Galderma
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- seborrheic dermatitis, T cell receptor transgenic mice, DBA/2 mice, CD4+ T-cell lymphopenia, opportunistic fungal infection, fluconazole, disease penetrance, adoptive transfer, bone marrow reconstitution, AIDS, inflammatory skin diseases
- MeSH terms
- Age Factors, Animals, Antigens, Disease Models, Animal, Lymphopenia, Mice, Inbred BALB C, Mice, Inbred DBA, Mice, Transgenic, Mycoses, Receptors, Antigen, T-Cell, Dermatitis, Seborrheic, Sexual Maturation, CD4-Positive T-Lymphocytes, Immunocompromised Host, Adoptive Transfer, Genetic Predisposition to Disease, Mice
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