Effector and memory CD8+ T cells as seen in immunity to malaria
Abstract
Transgenic (Tg) mice carrying a T-cell receptor (TCR) specific for a CD8(+) T-cell epitope expressed in pre-erythrocytic stages of Plasmodium yoelii has proven to be a valuable tool to advance our understanding of this anti-parasite T-cell response, as it occurs in vivo. The visualization of CD8(+) T cells in vivo and ex vivo greatly facilitated research aimed at characterizing basic features of this T-cell response such as the kinetics of differentiation and proliferation and the in vivo antigen presentation. Importantly, this research unveiled the existence of early self-regulatory mechanisms controlling the magnitude of the CD8(+) T-cell response and also identified CD4(+) T cells as critical elements in the development of memory populations. This review discusses our recent research using Tg mice and highlights our progress in understanding the CD8(+) T-cell-mediated immunity against malaria liver stages.
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The PSMD7 gene is involved in the processes of presenting antigens by the major histocompatibility complex (MHC) class I proteins to CD8+ T-lymphocytes.
“This gene is involved in the processes of presenting antigens by the major histocompatibility complex (MHC) class I proteins to CD8+ T-lymphocytes (Morrot and Zavala, 2004; Goldszmid and Sher, 2010; Jordan and Hunter, 2010).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Morrot and Zavala, 2004
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References 92 · Cited by 55
- Authors
- Morrot, A., & Zavala, F.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Zavala, Fidel
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-09-10
- Volume
- 201
- Issue
- 1
- Pages
- 291-303
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2160726246
- Cited by
- 55
- References
- 92
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 44375)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- CD8+ T cells, malaria immunity, Plasmodium yoelii, pre-erythrocytic stage, effector T cells, memory T cells, antigen presentation, CD4+ T cells, liver-stage immunity
- MeSH terms
- Animals, Humans, Immunologic Memory, Lymphocyte Activation, Malaria, Mice, Inbred BALB C, Plasmodium berghei, Plasmodium yoelii, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice
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