The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
IL‐12 and IL‐23: master regulators of innate and adaptive immunity
Abstract
Summary: Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell‐derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)‐23, a new member of the IL‐12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL‐12 and IL‐23 promote two distinct immunological pathways that have separate but complementary functions. IL‐12 is required for antimicrobial responses to intracellular pathogens, whereas IL‐23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression.
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Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Self-citationDivergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669
Self-citationMicrobial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586 · cited 1×
“synovial fluid of patients with Lyme arthritis (82), suggesting”
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Cited by
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585
Self-citationTH-17 cells in the circle of immunity and autoimmunity
Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007) · Nature Immunology · doi:10.1038/ni0407-345 · Cited by 1,517
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
Metadata
- Authors
- Langrish, C. L., McKenzie, B. S., Wilson, N. J., De Waal Malefyt, R., Kastelein, R. A., & Cua, D. J.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 202
- Issue
- 1
- Pages
- 96-105
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1966999437
- Cited by
- 753
- References
- 3
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Langrish, C. L., McKenzie, B. S., Wilson, N. J., De Waal Malefyt, R., Kastelein, R. A., & Cua, D. J. (2004). IL‐12 and IL‐23: master regulators of innate and adaptive immunity. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2004.00214.x
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