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Cited by 397Immunotherapy and Immune Responsesinterferon and immune responsesImmune Response and Inflammation

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

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Swiecki, Melissa, Colonna, Marco·2010·Immunological Reviews
DOI 10.1111/j.0105-2896.2009.00881.xPMC PMC3507434
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Abstract

Summary: Plasmacytoid dendritic cells (pDCs) are bone marrow‐derived cells that secrete large amounts of type I interferon (IFN) in response to viruses. Type I IFNs are pleiotropic cytokines with antiviral activity that also enhance innate and adaptive immune responses. Viruses trigger activation of pDCs and type I IFN responses mainly through the Toll‐like receptor pathway. However, a variety of activating and inhibitory pDC receptors fine tune the amplitude of type I IFN responses. Chronic activation and secretion of type I IFN in the absence of infection can promote autoimmune diseases. Furthermore, while activated pDCs promote immunity and autoimmunity, resting or alternatively activated pDCs may be tolerogenic. The various roles of pDCs have been extensively studied in vitro and in vivo with depleting antibodies. However, depleting antibodies cross‐react with other cell types that are critical for eliciting protective immunity, potentially yielding ambiguous phenotypes. Here we discuss new approaches to assess pDC functions in vivo and provide preliminary data on their potential roles during viral infections. Such approaches would also prove useful in the more specific evaluation of how pDCs mediate tolerance and autoimmunity. Finally, we discuss the emergent role of pDCs and one of their receptors, tetherin, in human immunodeficiency virus pathogenesis.

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  • DC cluster 2 may have contained plasmacytoid DCs.

    “The plasmacytoid DC-specific TFs such as Tcf4 and Runx2 were more active in DC cluster 2 than other DC clusters 22-24 ; thus, DC cluster 2 may have contained plasmacytoid DCs.”

    From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [23]

    The section ‘Generation of pDCs-less mice for the analysis of pDCs functions in vivo’ identifies E2-2/Tcf4 as a regulator of plasmacytoid DC development. Our copy does not identify Runx2 as a plasmacytoid DC-specific transcription factor or discuss DC cluster 2. The cluster assignment is the citing authors’ inference, but its cited transcription-factor rationale is only partly supported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Sorted by citations

Authors
Swiecki, M., & Colonna, M.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Colonna, Marco
ORCID
Colonna, Marco
Venue
Immunological Reviews
Publisher
Wiley
Published
2010-02-22
Volume
234
Issue
1
Pages
142-162
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
DOI
10.1111/j.0105-2896.2009.00881.x
PMC
PMC3507434
OpenAlex
W2159402147
Cited by
397
References
4
Citations by year
2026: 7 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 16 · 2021: 17 · 2020: 19 · 2019: 19 · 2018: 14 · 2017: 24 · 2016: 31 · 2015: 21 · 2014: 36 · 2013: 41 · 2012: 55
FWCI
4.16
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5t32dk007296-35)
  • U.S. Public Health Service (A1067854-03)
  • National Institute of Allergy and Infectious Diseases (U19AI067854)
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32-DK007296, 5 T32 DK007296-30)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
plasmacytoid dendritic cells, type I interferon, viral infection, autoimmunity, immune tolerance, Toll-like receptors, alternative activation, HIV pathogenesis, tetherin, innate immunity
MeSH terms
Bone Marrow Stromal Antigen 2, Animals, Dendritic Cells, HIV, Humans, Immune Tolerance, Immunity, Innate, Interferon Type I, Membrane Glycoproteins, Receptors, Immunologic, Virus Diseases, Signal Transduction, Autoimmunity, HIV Infections, Antigens, CD, CD8-Positive T-Lymphocytes, Mice, Adaptive Immunity, GPI-Linked Proteins

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