The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis
Open accessAbstract
Summary. Classic studies of tuberculosis (TB) revealed morphologic evidence of considerable heterogeneity of macrophages (MØs), but the functional significance of this heterogeneity remains unknown. We have used newly available specific antibodies for selected membrane and secretory molecules to examine the phenotype of MØs in situ in a range of South African patients with TB, compared with sarcoidosis. Patients were human immunodeficiency virus‐negative adults and children, and the examined biopsy specimens included lung and lymph nodes. Mature pulmonary MØs (alveolar, interstitial, epithelioid and multinucleated giant cells) selectively expressed scavenger receptor type A and a novel carboxypeptidase‐like antigen called carboxypeptidase‐related vitellogenin‐like MØ molecule (CPVL). CPVL did not display enhanced expression in sarcoidosis, vs. TB patients, as observed with angiotensin‐converting enzyme (ACE), a related molecule. Immunocytochemical studies with surfactant proteins (SP)‐A and ‐D showed that type II alveolar cells expressed these collectins, as did MØs, possibly after binding of secreted proteins. Studies with an antibody specific for the C‐terminus of fractalkine, a tethered CX3C chemokine, confirmed synthesis of this molecule by bronchiolar epithelial cells and occasional endothelial cells. These studies provide new marker antigens and extend previous studies on MØ differentiation, activation and local interactions in chronic human granulomatous inflammation in the lung.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In giant cell myocarditis and cardiac sarcoidosis, macrophages are a significant contributor to the formation of multinucleated giant cells or granulomas.
“In well-known forms of autoimmune myocarditis such as giant cell myocarditis and cardiac sarcoidosis, macrophages have been identified as a significant contributor to the formation of multinucleated giant cells or granulomas”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [109]
The Discussion (page unavailable) says macrophages are prominent in granulomatous lesions and are associated with epithelioid and giant-cell formation; the Results describe giant cells in pulmonary sarcoidosis granulomas. The paper examines lung and lymph-node tissue, not cardiac sarcoidosis or giant cell myocarditis, so it does not establish the claim for those cardiac conditions. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013
Self-citation
Flagged first, then by citations
Research works printed but not linked: 49
- Adams D.O., 1976, The granulomatous inflammatory response, Am. J. Pathol., 84, 164
- Bermudez. L.E., 1996, Mycobacterium tuberculosis invades and replicates within type II alveolar cells, Infect. Immunity, 64, 1400, 10.1128/iai.64.4.1400-1406.1996 · DOI
- 10.1378/chest.107.3.706 · DOI
- 10.1152/ajplung.00187.2002 · DOI
- 10.1152/ajplung.2001.281.6.L1453 · DOI
- 10.1146/annurev.immunol.20.081501.125851 · DOI
- Christensen P.J., 1997, Lung Macrophages and Dendritic Cells in Health and Disease., 283
- 10.1084/jem.181.1.257 · DOI
- 10.1385/1-59259-320-8:205 · DOI
- Cunningham M.R., 2001, The immunological role of respiratory tract epithelium, Mod. Asp. Immunobiol., 5, 204
- 10.1126/science.8456300 · DOI
- Dannenberg A.M., 1994, Tuberculosis. Pathogenesis, Protection and Control., 459
- Ernst J., 1998, Macrophage receptors for Mycobacterium tuberculosis, Infect. Immunity, 66, 1277, 10.1128/IAI.66.4.1277-1281.1998 · DOI
- 10.1128/IAI.68.5.2827-2836.2000 · DOI
- 10.1038/364343a0 · DOI
- 10.1016/S0092-8674(01)00236-7 · DOI
- Gordon S., 1997, Lung Macrophages and Dendritic Cells in Health and Disease, 3
- 10.1161/01.ATV.19.3.461 · DOI
- 10.4049/jimmunol.170.5.2302 · DOI
- 10.1084/jem.186.9.1431 · DOI
- 10.1016/S1286-4579(02)01611-8 · DOI
- Hirsch C.S., 1994, Complement receptor‐mediated uptake and tumor necrosis factor α‐mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages, J. Immunol., 152, 743, 10.4049/jimmunol.152.2.743 · DOI
- Holmskov U., 2000, Acta Pathologica, Microbiologica, et Immunologica Scandinavica., 1
- 10.1172/JCI118461 · DOI
- 10.1002/eji.1830250224 · DOI
- 10.3109/10641968709164217 · DOI
- 10.1007/978-94-015-8070-0_49 · DOI
- Kondo A., 1998, Signifance of serum surfactant protein‐D (SP‐D) level in patients with pulmonary tuberculosis, Kekkaku, 73, 585
- 10.1146/annurev.bi.63.070194.003125 · DOI
- 10.1164/ajrccm/147.3.723 · DOI
- 10.1016/S0304-4165(02)00320-3 · DOI
- 10.1016/S0002-9440(10)64034-5 · DOI
- 10.4049/jimmunol.164.11.5866 · DOI
- 10.1006/geno.2000.6484 · DOI
- 10.1111/j.1365-2141.1989.tb00210.x · DOI
- 10.4049/jimmunol.164.6.3368 · DOI
- Orme I.M., 1994, Tuberculosis, Pathogenesis, Protection and Control., 113
- 10.1128/IAI.68.4.1953-1963.2000 · DOI
- 10.1073/pnas.93.22.12456 · DOI
- 10.1016/S0167-5699(98)01289-4 · DOI
- 10.1038/35085034 · DOI
- Schlesinger L.S., 1997, Lung Macrophages and Dendritic Cells in Health and Disease., 437
- Schreiber R.D., 2002, The Macrophage, 73
- SiltzbachL.E. ed. (1976)Seventh International Conference on Sarcoidosis and Other Granulomatous Disorders.Ann. N Y Acad. Sci.278 pp.1–751.
- 10.1073/pnas.76.12.6646 · DOI
- Spector W.G., 1969, The granulomatous inflammatory exudate, Int. Rev. Exp. Pathol., 8, 1
- 10.1016/S0952-7915(02)00355-2 · DOI
- 10.1111/j.1749-6632.1994.tb39802.x · DOI
- 10.1084/jem.180.2.705 · DOI
Cited by
Sorted by citations
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- Stanton, L., Fenhalls, G., Lucas, A., Gough, P., Greaves, D. R., Mahoney, J. A., Helden, P. V., & Gordon, S.
- Affiliations
- Stellenbosch University (ZA)
- University of Oxford (GB)
- Corresponding author
- Gordon, Siamon
- Venue
- International Journal of Experimental Pathology
- Publisher
- Wiley
- Published
- 2003-12
- Volume
- 84
- Issue
- 6
- Pages
- 289-304
- ISSN
- 0959-9673 (ISSN-L)
- 1365-2613
- PMC
- PMC2517569
- OpenAlex
- W1929490466
- Cited by
- 42
- References
- 1
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2021: 4 · 2020: 3 · 2018: 3 · 2016: 1 · 2014: 3 · 2012: 3
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Experimental Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- South African Medical Research Council
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoidosis and Beryllium Toxicity Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- macrophage heterogeneity, pulmonary tuberculosis, sarcoidosis, angiotensin-converting enzyme, surfactant protein A, surfactant protein D, fractalkine, alveolar macrophages, epithelioid cells, multinucleated giant cells, granulomatous inflammation, lung biopsy, lymph nodes, bronchiolar epithelial cells
- MeSH terms
- CD68 Molecule, Adult, Carboxypeptidases, Child, Child, Preschool, Female, Humans, Peptidyl-Dipeptidase A, Macrophages, Male, Membrane Proteins, Middle Aged, Receptors, Immunologic, Tuberculosis, Pulmonary, Antigens, Differentiation, Myelomonocytic, Biomarkers, Antigens, CD, Immunophenotyping, Macrophages, Alveolar, Sarcoidosis, Pulmonary, Receptors, Lipoprotein, Chemokines, CX3C, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein D, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, Chemokine CX3CL1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
