The DOI matches its Crossref record.
Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer
Open accessAbstract
p53 protein has been frequently detected at high levels in the nuclei of human breast cancer cells. We analyzed inununohistochemically the association between nuclear localization of p53 protein and clinical and histological parameters of breast cancer patients. Surgically resected tissues of 73 primary breast cancers were processed by acetone fixation and paraffin embedding and examined using an anti‐p53 monoclonal antibody, Pabl801. p53 immunoreactivity was detected in the nuclei of cancer cells in 17 cases (23%). The nuclear p53 immunoreaction was closely associated with overexpression of c‐erb B‐2 protein (P<0.05), high histologic grade (P<0.01), advanced clinical stage (P<0.05), and negative estrogen receptor status (P< 0.01). When 31 cases which had been followed up for more than 50 months were examined, a positive nuclear p53 immunoreaction was found to he significantly associated with shorter overall survival of patients (P<0.01). These results suggest that inununohistochemical examination of nuclear p53 protein is clinically useful as an indicator of breast cancer aggressiveness.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Sjogren, S., Inganas, M., Norberg, T., Lindgren, A., Nordgren, H., Holmberg, L., & Bergh, J. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.3-4.173 · Cited by 381
Nemunaitis, J., Swisher, S. G., Timmons, T., Connors, D., Mack, M., Doerksen, L., Weill, D., Wait, J., Lawrence, D. D., Kemp, B. L., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.3.609 · Cited by 322
Mutational spectrum of p53 mutations in primary breast and ovarian tumors
Feki, A., & Irminger-Finger, I. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.07.002 · Cited by 139
Günther, T., Schneider-Stock, R., Ryš, J., Niezabitowski, A., & Roessner, A. (1997) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01240122 · Cited by 28
Pare, R., Soon, P. S., Shah, A., & Lee, C. S. (2019) · PLOS ONE · doi:10.1371/journal.pone.0214604 · Cited by 23
Metadata
- Authors
- Iwaya, K., Tsuda, H., Hiraide, H., Tamaki, K., Tamakuma, S., Fukutomi, T., Mukai, K., & Hirohashi, S.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 1991-07
- Volume
- 82
- Issue
- 7
- Pages
- 835-840
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W2034639401
- Cited by
- 171
- References
- 0
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer. https://app.cochat.ai/papers/10.1111/j.1349-7006.1991.tb02710.x
- The paper
- Iwaya, K., Tsuda, H., Hiraide, H., Tamaki, K., Tamakuma, S., Fukutomi, T., Mukai, K., & Hirohashi, S. (1991). Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.1991.tb02710.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
