The DOI matches its Crossref record.
Survivin as a Radioresistance Factor in Pancreatic Cancer
Open accessAbstract
We examined whether survivin acts as a constitutive and inducible radioresistance factor in pancreatic cancer cells. Using a quantitative TaqMan reverse transcription‐polymerase chain reaction for survivin mRNA in five pancreatic cancer cell lines, we found an inverse relationship between survivin mRNA expression and radiosensitivity. PANC‐1 cells, which had the highest survivin mRNA levels, were most resistant to X‐irradiation; MIAPaCa‐2 cells, which showed the least survivin mRNA expression, were the most sensitive to X‐irradiation. Our results suggested that survivin could act as a constitutive radioresistance factor in pancreatic cancer cells. To determine whether radioresistance is enhanced by induction of survivin expression by irradiation, PANC‐1 and MIAPaCa‐2 cells were subjected to sublethal doses of X‐irradiation followed by a lethal dose. Survivin mRNA expression was increased significantly in both PANC‐1 and MIAPaCa‐2 cell lines by pretreatment with a sublethal dose of X‐irradiation, as was cell survival after exposure to the lethal dose. In this system, enzymatic caspase‐3 activity was significantly suppressed in cells with acquired resistance. These results suggest that survivin also acts as an inducible radioresistance factor in pancreatic cancer cells. Survivin, then, appears to enhance radioresistance in pancreatic cancer cells; inhibition of survivin mRNA expression may improve the effectiveness of radiotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Microtubules, microtubule-interfering agents and apoptosis
Mollinedo, F., & Gajate, C. (2003) · Apoptosis · doi:10.1023/a:1025513106330 · Cited by 477
Survivin: a unique target for tumor therapy
Garg, H., Suri, P., Gupta, J. C., Talwar, G. P., & Dubey, S. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0326-1 · Cited by 437
Li, F., & Sethi, G. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.01.002 · Cited by 398
Survivin: A new target for anti-cancer therapy
Ryan, B. M., O’Donovan, N., & Duffy, M. J. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.05.003 · Cited by 379
Li, S.-D., & Huang, L. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060039w · Cited by 282
Metadata
- Authors
- Asanuma, K., Moriai, R., Yajima, T., Yagihashi, A., Yamada, M., Kobayashi, D., & Watanabe, N.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 2000-11
- Volume
- 91
- Issue
- 11
- Pages
- 1204-1209
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W2010831478
- Cited by
- 205
- References
- 0
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Survivin as a Radioresistance Factor in Pancreatic Cancer. https://app.cochat.ai/papers/10.1111/j.1349-7006.2000.tb00906.x
- The paper
- Asanuma, K., Moriai, R., Yajima, T., Yagihashi, A., Yamada, M., Kobayashi, D., & Watanabe, N. (2000). Survivin as a Radioresistance Factor in Pancreatic Cancer. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.2000.tb00906.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
