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Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteins
Open accessAbstract
Human papillomaviruses (HPV) are believed to be the primary causal agents for development of pre‐neoplastic and malignant lesions of the uterine cervix, and high‐risk types such as type 16 and 18 are associated with more than 90% of all cervical carcinomas. The E6 and E7 genes of HPV are thought to play causative roles, since E6 promotes the degradation of p53 through its interaction with E6AP, an E3 ubiquitin ligase, whereas E7 binds to the retinoblastoma protein (pRb) and disrupts its complex formation with E2F transcription factors. Although prophylactic vaccines have become available, it is still necessary to clarify the mechanisms of HPV‐induced carcinogenesis because of the widespread nature of HPV infection. Approximately 493 000 new cases of cervical cancer are diagnosed each year with approximately 274 000 mortalities due to invasive cervical cancer. In the present article, the mechanisms of HPV16 E6‐ and E7‐induced multistep carcinogenesis and recently identified functions of these onco‐proteins are reviewed. (Cancer Sci 2007; 98: 1505–1511)
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TL;DR
This review summarizes how high-risk HPV E6 and E7 oncoproteins drive cervical carcinogenesis by inactivating p53 and pRb family proteins and by targeting additional cellular pathways. It emphasizes that overexpression of E6/E7, usually after viral integration, is a bottleneck step that cooperates with further genetic and epigenetic changes.
Key findings
- High-risk HPV types (16, 18, 31, 33, 45, 51, 52, 58, etc.) are associated with more than 90% of cervical cancers; HPV16 accounts for approximately half and HPV18 for another 10–20%. Approximately 493,000 new cervical cancer cases and 274,000 deaths occur annually.
- E6 promotes degradation of p53 through interaction with E6AP, an E3 ubiquitin ligase, while E7 binds pRb family proteins and disrupts pRb–E2F complexes; together they cause polyploidy and genomic instability.
- E6 has p53-independent functions, including hTERT/telomerase induction and degradation of PDZ-domain proteins such as DLG, Scribble, MUPP1, MAGI-1/-2/-3, GIPC, PATJ, PTPN3, and PSD95; E7 targets many proteins including p27, p21, p600, and PP2A.
- Integration and high-level E6/E7 expression are proposed as the bottleneck step; additional events reported in cervical cancers include PIK3CA, c-myc, ErbB2, and cIAP1 amplification, ras mutation, and decreased PTEN and TSLC1 expression.
Methods
- Narrative review; no primary experimental data, sample, or systematic analysis are reported.
- Synthesizes published literature and the authors’ recent work on HPV16 E6- and E7-induced multistep carcinogenesis, the HPV life cycle, and target proteins of E6 and E7 (Table 1; Figs 1–5).
Limitations
- The paper does not state formal limitations; it notes that further exploration is needed for TSC2/Tuberin as a possible E6 target.
- Evident from the text: this is a narrative review without stated systematic search or inclusion criteria, and some mechanistic claims rely on cited reviews, speculation, or a personal communication (A. Suhrbier, 2007) regarding E7-mediated pRb cleavage.
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57 Sources not found · 14 Own interpretation
In the paper
“The most manifest function of the E6 protein is to promote the degradation of p53 through its interaction with a cellular protein, E6 associated protein (E6AP), an E3 ubiquitin ligase (9)”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
What the sources say
- Not matchedcites [9]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates a cause- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
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In the paper
“in the presence of E6, a repressor complex of TERT promoter, containing USF1 and USF2, is replaced by Myc, which corresponds to higher levels of TERT transcription and consequently, telomerase activity.(35)”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
What the sources say
- Not matchedcites [35]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates a cause- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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In the paper
“The interaction of E7 with cyclin-dependent kinase (CDK)2/cyclin A, (60) as well as CDK2/cyclin E, (61) has also been reported.”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > IRF1
What the sources say
- Not matchedcites [60]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates an association- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
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In the paper
“For evasion of the immune system, E7 also interacts with p48, (64) as well as IRF1.(8)”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > IRF1
What the sources say
- Not matchedcites [64]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates an association- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“E6 and Myc interaction has been shown to activate the telomerase reverse transcriptase promoter, (34)”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
What the sources say
- Not matchedcites [34]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates a cause- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > Tyk2
“TSC2 (tubulin)”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
“The tumor suppressor gene TSC2 product, Tuberin”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > HPV infection and HPV-induced transformation
“The ultimate development of cervical cancer is rarely accompanied by high expression of E6 and E7 proteins.”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > HPV infection and HPV-induced transformation
“CIN III (severe dysplasia, carcinoma in situ) and invasive cancer lesions often display high-level expression of E6 and E7”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
“Therefore, its down regulation through p53 with E6/E6AP has been revealed as a novel tumor suppressor mechanism blocking development of HPV-induced cervical carcinogenesis.”
§ Basic mechanisms of high-risk human papillomavirusinduced carcinogenesis: Roles of E6 and E7 proteins > The functions of HPV onco-proteins E6 and E7
“its down-regulation by E6 might contribute to the development of cervical cancer.”
Citations
Cites
Epidemiologic classification of human papillomavirus types associated with cervical cancer
Muñoz, N., Bosch, F. X., de Sanjosé, S., Herrero, R., Castellsagué, X., Shah, K. V., Snijders, P. J. F., & Meijer, C. J. L. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021641 · Cited by 6,249
Papillomaviruses and cancer: from basic studies to clinical application
Hausen, H. Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc798 · Cited by 4,094
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,691
Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer
Storey, A., Thomas, M., Kalita, A., Harwood, C. A., Gardiol, D., Mantovani, F., Breuer, J., Leigh, I. M., Matlashewski, G., & Banks, L. (1998) · Nature · doi:10.1038/30400 · Cited by 971
Notch1 functions as a tumor suppressor in mouse skin
Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C., Clevers, H. C., Dotto, G. P., & Radtke, F. (2003) · Nature Genetics · doi:10.1038/ng1099 · Cited by 969
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., METZGER, D., Chambon, P., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3427 · Cited by 867
The Ets family of transcription factors
Wasylyk, B., Hahn, S. L., & Giovane, A. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19864.x · Cited by 839
Mechanisms of human papillomavirus-induced oncogenesis
Münger, K., Baldwin, A., Edwards, K. M., Hayakawa, H., Nguyen, C. L., Owens, M., Grace, M., & Huh, K. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.11451-11460.2004 · Cited by 815
Telomerase activation by the E6 gene product of human papillomavirus type 16
Klingelhutz, A. J., Foster, S. A., & McDougall, J. K. (1996) · Nature · doi:10.1038/380079a0 · Cited by 660
Cited by
Items 401–500 of 530
Nicolau-Júnior, N. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2013.tde-13062013-092311 · Cited by 2
Pan, D., Gascard, P. D., Caruso, J. A., Chen‐Tanyolac, C., Sangwan, V., Bertos, N., Camilleri‐Broët, S., Bérubé, J., Oikonomopoulos, S., Strasser, M. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.661192 · Cited by 2
Cervical Cancer: pathology, clinical records, and nursing contributions
Alshahri, S. S. M., Alanazi, A. T., Kilabi, K. M. H., Almutairi, F. K., Salloum, S. A. S. A., Alnajim, O. A., Aldhahri, A. S., Alzahrani, M. A., Alreshidi, M. S., Alshehri, A. F., et al. (2024) · International Journal of Health Sciences · doi:10.53730/ijhs.v8ns1.15346 · Cited by 1
Doğan, B. (2025) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2025.25817 · Cited by 1
Sohel, H. I., Zahan, U. F., Ishikawa, M., Kanno, K., Yamashita, H., Nakayama, K., & Kyo, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052393 · Cited by 1
Li, Y., & Zhou, S. (2026) · The International Journal of Biological Markers · doi:10.1177/03936155261428136 · Cited by 1
Yan, L., Yin, H., Shi, L., Ding, B., Liu, C., Wang, Y., & Fu, C. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s542859 · Cited by 1
Silencing of E6/E7 Expression in Cervical Cancer Stem-Like Cells
Gu, W., McMillan, N. A. J., & Yu, C. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2013-6_12 · Cited by 1
Mohammad, H. F. (2012) · EngagedScholarship @ Cleveland State University (Cleveland State University) · Cited by 1
Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers
Graldine, D., Analle, D., Philippe, D., & Sve, S. (2012) · InTech eBooks · doi:10.5772/29999 · Cited by 1
Human Papillomaviruses Oncoproteins
Anton, G., Plesa, A., Bleoţu, C., Botezatu, A., Anton, M., Irina, L., & Stoi, M. (2013) · InTech eBooks · doi:10.5772/55342 · Cited by 1
Rôle des oncoprotéines virales E6 et E7 dans l’expression de p16 INK4a
Si‐Mohamed, A. (2010) · Annales de Pathologie · doi:10.1016/j.annpat.2010.07.037 · Cited by 1
Orale Kontrazeption und das Risiko gynäkologischer Tumoren
Ponnath, M., & Ortmann, O. (2011) · Der Gynäkologe · doi:10.1007/s00129-010-2665-7 · Cited by 1
Human Papillomavirus-Related Cancers
de Freitas, A. C., Gurgel, A. P. A. D., Chagas, B. S., do Amaral, C. M. M., Coimbra, E. C., de Lima, É. G., Neto, J. D. C. S., Leitão, M. D. C. G., & de Lima, R. D. C. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-20669-1_13 · Cited by 1
Hypermutated Colorectal Cancer and Neoantigen Load
Glaire, M. A., & Church, D. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-43063-8_8 · Cited by 1
Ara, R., Pervin, S., Khatun, S., Shahera, U., Sultana, M., & Aktar, M. N. (2020) · Indian Journal of Gynecologic Oncology · doi:10.1007/s40944-020-00416-5 · Cited by 1
Azimi, T., Bagheri, M., Paryan, M., Khansarinejad, B., Zamani, A., & Mondanizadeh, M. (2020) · مجله دانشگاه علوم پزشکی اراک · doi:10.32598/jams.23.3.3686.3 · Cited by 1
Human DNA Tumor Viruses and Oncogenesis
Purushothaman, P., & Verma, S. C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416002-6.00007-9 · Cited by 1
Assessment of HPV16 infection in patients with laryngeal cancer
Mucha-Małecka, A., Biesaga, B., Janecka-Widła, A., Przewoźnik, M., & Małecki, K. (2021) · Polish Journal of Pathology · doi:10.5114/pjp.2021.104659 · Cited by 1
Blagosklonny, M. V., & Gudkov, A. V. (2010) · Oncotarget · doi:10.18632/oncotarget.23437 · Cited by 1
Unusual exuberant koilocytic proliferation in odontogenic keratocyst
Sarode, G. S., Sarode, S. C., Sengupta, N., Ghone, U., & Prasad, S. (2022) · Oral Surgery · doi:10.1111/ors.12790 · Cited by 1
Sinha, A., Ghosh, S., Ghosh, A., Ghosh, A., Mathai, S., Bhaumik, J., Mukhopadhyay, A., Maitra, A., Biswas, N. K., & Sengupta, S. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae019 · Cited by 1
Carse, S., Reid, T., Madsen, J., Clark, H. W., Kirjakulov, A., Bergant, M., & Schäfer, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147712 · Cited by 1
Hutcheson, J. D., Conway, D. I., Kumar, S., Wiseman, C., Chakraborty, S., Skrypkin, E., Horan, M., Gunning, A., Williams, C. K., Kuperwasser, C., et al. (2025) · Diagnostics · doi:10.3390/diagnostics15070825 · Cited by 1
Studies on the Expression of P16INK4AmRNA in Cervical Dysplasias
Simanavičienė, V., Popendikytė, V., Gudlevičienė, Ž., Armalytė, S., Kirkutyte, A., Shikova, E., & Žvirblienė, A. (2012) · Biotechnology & Biotechnological Equipment · doi:10.5504/50yrtimb.2011.0015 · Cited by 1
Viral Malignancies in HIV-Associated Immune Deficiency
Kumar, P., Minhas, V., & Wood, C. A. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0016-5_32 · Cited by 1
Cardeal, L. B. D. S. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2011.tde-28012011-113405 · Cited by 1
Development of New Human Papillomavirus Vaccines
Rodr�guez-Cerdeira, C., Dez-Moreno, S., Snchez, E., & Alb, A. (2012) · InTech eBooks · doi:10.5772/28099 · Cited by 1
Construção de vetores para superexpressão da proteína L1 do HPV16 em Pichia pastoris
Silva, J. R. S. N. E. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2010.tde-26112010-104443 · Cited by 1
The Role of Tight and Adherens Junctions in Cervical Neoplasia
Cunniffe, C. (2014) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d72p47 · Cited by 1
Smal, C. (2010) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) · Cited by 1
Fatores dietéticos e persistência da infecção por HPV em homens
Lopes, R. D. V. C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.6.2015.tde-21092015-113133 · Cited by 1
Design and delivery strategies of alphavirus replicon-based cervical cancer vaccines
van de Wall, M.-N. S. (2018) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1
Galla chinensis exhibits anticancer activity in HPV-16 infected cervical cancer cellsPreprint
Zhang, X., Ma, X., Wang, Z., Dang, H., Wei, Y., Han, B. R., & Ren, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1402412/v1 · Cited by 1
Cai, H., Feng, Y., Fan, P., Guo, Y., Kuerban, G., Chang, C., Yao, X., Peng, Y., & Wang, R. (2021) · Research Square · doi:10.21203/rs.3.rs-209456/v1 · Cited by 1
Yin, Z., Feng, T., Xu, Q., Dai, W., Ni, M., Ni, J., & Lou, H. (2024) · eLife · doi:10.7554/elife.101887.1 · Cited by 1
Shaw, C. (2009) · DukeSpace (Duke University)
Utami, T. W. (2016) · Indonesian Journal of Obstetrics and Gynecology · doi:10.32771/inajog.v2i3.398
Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
Li, X. (2013) · Lund University Publications (Lund University)
Nucleoside analogue drugs and human papillomavirus associated neoplasia
Flynn, Á. S. (2013) · ORCA Online Research @Cardiff (Cardiff University)
Shim, A. R., Choi, J., Yun, S. H., Lee, M., Lee, M. K., & Kim, S. W. (2011) · Korean Journal of Obstetrics & Gynecology · doi:10.5468/kjog.2011.54.10.634
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Karolina, G.-S. (2013) · Biblioteka Uniwersytetu Medycznego w Poznaniu
Cha, J.-Y., Cho, T.-I., Park, T.-Y., So, J.-S., Choi, S.-K., & Park, E.-S. (2008) · Korean Journal of Gynecologic Oncology · doi:10.3802/kjgo.2008.19.1.17
Vertical Transmission of Human Papillomavirus From Mother to Fetus: Literature Review
Porterfield, S. P. (2011) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2011.05.003
Development of chimeric candidate vaccine against HPV18: a proof of concept
Wahiduzzaman, M., Sharma, C., Dey, B., Bhatla, N., & Singh, N. (2015) · Immunologic Research · doi:10.1007/s12026-015-8650-4
Ishida, K., Nagasaki, M., Kobayashi, M., 中川, 達., Nabika, T., & Taniyama, K. (2011) · ISRN Pathology · doi:10.5402/2011/219790
Human papillomaviruses and their association with squamous cell carcinoma of the conjunctiva
Agaba, C. A. (2009) · Figshare
da Conceição, M. E. F., & Freitas, N. (2012)
Paulista, U. N. E., Filho, M., & Araraquara, C. D. (2011)
Best Practice & Research Clinical Obstetrics and Gynaecology
Brown, A. J., & Trimble, C. L. (2012)
Lira, R. C. P. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2009.tde-16082014-153851
Screening for Gynecological Cancers
Salhan, S., & Singh, V. (2011) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/11481_39
Human Papilloma Virus (HPV) Vaccines: Scope and Implications
Singh, R. K., Satapathy, S., & Singh, A. (2016) · Translational Medicine · doi:10.4172/2161-1025.1000180
PROGRAMA DE PÓS-GRADUAÇÃO EM GENÉTICA
Moreira, H. T. (2015)
The Relationship of Food Security, Cervical Health, and Produce Intake in Rural Appalachia
Hewage, S. S. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
Estudo de letalidade sintética em células transformadas por papilomavírus humano (HPV).
Abjaude, W. D. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-15052017-144525
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Utami, T. W., Ibrahim, F., Purwoto, G., Tiffani, W. L., Aziz, M. F., & Andrijono, A. (2017) · Indonesian Journal of Obstetrics and Gynecology · doi:10.32771/inajog.v5i1.465
Faro, A. (2011) · University of the Western Cape Electronic Theses and Dissertations Repository (University of the Western Cape)
Human Papillomavirus ve Oral ve Orofarinjeal Karsinomadaki Rolü
Buch, S. A., Babu, S., Castelino, R., Rao, S., Rao, K., & Kamath, J. S. (2017) · Arşiv Kaynak Tarama Dergisi · doi:10.17827/aktd.312211
Viral Carcinogenesis of Oral Region and Recent Trends in Treatment
Sharma, M., Astekar, M. S., Soi, S., Manjunatha, B. S., & Shetty, D. C. (2015) · Recent Patents on Biomarkerse · doi:10.2174/2210309005666150505183429
UMEZAWA, T., Ochiai, K., Yamada, K., Ochiai, K., Okamoto, A., Isonishi, S., Tsukumo, Y., Sawabe, M., & Ikegami, M. (2017) · 日本臨床細胞学会雑誌 · doi:10.5795/jjscc.56.276
Boczek, U. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6890
Umebayashi, M., Ohba, S., Koga, T., Kawai, Y., Fujita, S., & Asahina, I. (2018) · Japanese Journal of Oral & Maxillofacial Surgery · doi:10.5794/jjoms.64.502
Advances in the Relationship between Human Papillomavirus Infection and Lung Cancer
戴, 晓. (2018) · Advances in Clinical Medicine · doi:10.12677/acm.2018.89137
Venancio, P. A. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2018.tde-12112018-124550
徳丸, 裕., 藤井, 正., 羽生, 昇., & 矢島, 陽. (2010) · 耳鼻と臨床 · doi:10.11334/jibi.56.s21
Rani, R., Singh, D. A. K., Khan, S., & Islam, P. N. (2019) · International Journal of Medical and Biomedical Studies · doi:10.32553/ijmbs.v3i5.259
Gollwitzer, T. H. (2019) · University of Regensburg Publication Server (University of Regensburg) · doi:10.5283/epub.40183
Gonçalves, C. A. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.22.2019.tde-23102019-143239
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Neagu, G., & Moroti-Constantinescu, R. V. (2021) · ORL ro · doi:10.26416/orl.51.2.2021.4948
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Talbot, A. P. (2009) · Digital WPI
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Maeda, H. (2010) · Japanese Journal of Oral & Maxillofacial Surgery · doi:10.5794/jjoms.56.464
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吴, 瑶. (2018) · Advances in Clinical Medicine · doi:10.12677/acm.2018.810155
Song, Z., Deng, J., Li, Q., Cui, Y., Ding, X., He, J., Liu, Y., Ju, Z., & Fang, L. (2020) · doi:10.21203/rs.3.rs-67643/v1
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Zhu, Y., Konohana, I., Okita, H., & Kurihara, Y. (2022) · 日本臨床皮膚科医会雑誌 · doi:10.3812/jocd.39.567
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Cooney, T. R. (2020) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.22783022
Gonçalves, R. V. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.60.2022.tde-19072023-144204
Liewchalermwong, S. (2019) · Chula Digiverse · doi:10.58837/chula.the.2019.356
Hung, T. M., Son, H. X., Bang, L. V. N., & Duyệt, L. V. (2024) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2023.105546
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Xiangping, T., Khan, J. M., Sajjad, S. S., Khwaja, S., Yongxiang, Y., & Li, J. (2024) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.53555/jptcp.v31i2.4476
Cai, H., Feng, Y., Fan, P., Guo, Y., Kuerban, G., Chang, C., Yao, X., Peng, Y., & Wang, R. (2021) · Figshare · doi:10.6084/m9.figshare.16633328
Cai, H., Feng, Y., Fan, P., Guo, Y., Kuerban, G., Chang, C., Yao, X., Peng, Y., & Wang, R. (2021) · Figshare · doi:10.6084/m9.figshare.16633331
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Giourgos, G. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1004474
Yaz, H. (2024) · Journal of Clinical and Nursing Research · doi:10.26689/jcnr.v8i7.7891
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Singh, P., Negi, S. S., Arora, R. D., & Nagarkar, N. M. (2024) · Springer eBooks · doi:10.1007/978-981-97-4480-0_26
Carolina Oliva, G., Carrillo-Beltrán, D., Osorio, J. C., Gallegos, I., Carvajal, F., V, Mancilla-Miranda, C., Paul Boettiger, B., Boccardo, E., & Aguayo, F. (2024) · Infectious Agents and Cancer · doi:10.1186/s13027-024-00609-z
Yin, Z., Feng, T., Xu, Q., Dai, W., Ni, M., Ni, J., & Lou, H. (2024) · Qeios · doi:10.32388/fjchwg
Yin, Z., Feng, T., Xu, Q., Dai, W., Ni, M., Ni, J., & Lou, H. (2024) · Qeios · doi:10.32388/fjchwg.2
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Guindani, M. E., Schwartz, K. L., Belasque, M. F., KAKUNO, M. L., Possetti, A. Y. S., Carmona, B. M., de Oliveira, G. V., Eduardo, G. E. F., CAMARGO, J. S. D., & SOUZA, M. C. M. D. (2025) · doi:10.59290/978-65-6029-209-3.12
Liu, R.-C., Ji, Y.-M., Huang, J., Du, Y., Zhong, Y.-M., & Sheng, X. (2025) · Oncology Letters · doi:10.3892/ol.2025.15021
Yin, Z., Feng, T., Xu, Q., Dai, W., Ni, M., Ni, J., & Lou, H. (2025) · Qeios · doi:10.32388/fjchwg.3
Metadata
- Authors
- Narisawa‐Saito, M., & Kiyono, T.
- Affiliations
- National Cancer Center Research Institute (JP)
- Corresponding author
- Kiyono, Tohru
- ORCID
- Kiyono, Tohru
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2007-07-23
- Volume
- 98
- Issue
- 10
- Pages
- 1505-1511
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- PMC
- PMC11158331
- OpenAlex
- W2011499737
- Cited by
- 528
- References
- 85
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 46 · 2023: 24 · 2022: 33 · 2021: 43 · 2020: 32 · 2019: 24 · 2018: 36 · 2017: 27 · 2016: 23 · 2015: 25 · 2014: 25 · 2013: 26 · 2012: 27
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- human papillomavirus, HPV16, HPV 18, cervical cancer, carcinogenesis, E6 oncoprotein, E7 oncoprotein, p53 degradation, UBE3A, retinoblastoma protein, E2F transcription factors, viral oncogenesis, HPV vaccine
- MeSH terms
- Cell Transformation, Neoplastic, Cell Transformation, Viral, Uterine Cervical Neoplasms, Female, Humans, Oncogene Proteins, Viral, Repressor Proteins, Papillomaviridae, Papillomavirus Infections, Papillomavirus E7 Proteins
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