The incidence of Crohn’s disease in Cardiff over the last 75 years: an update for 1996–2005
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Summary: Background The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is still rising or has reached a plateau. Aims To update the long‐term incidence study of Crohn’s disease in Cardiff for 1996–2005, to investigate whether incidence is still rising and to study changes in disease characteristics over time. Method Crohn’s cases identified by retrospective analysis of hospital records as in previous studies in Cardiff. Results Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 × 10 6 per year (95% confidence interval: 58–76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in those with terminal ileal disease. There remains a strong female preponderance (F:M 1.6:1) as in previous studies. The incidence in children under age 16 continues to rise, and the median age at diagnosis has fallen slightly. Conclusion Crohn’s disease incidence continues to rise slowly in Cardiff with a continuing increase in those presenting with colonic disease, which is now the commonest disease pattern.
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In Cardiff, Wales, Crohn's disease incidence was low and flat in the 1930s and 1940s, spiked to 9.1 per 100,000 in 1983, and then stabilized at 6.0 per 100,000 in 1993 and 7.0 per 100,000 in 2003.
“Initially, the incidence was low and flat (0.27 and 0.09 per 100,000 in 1933 and 1943, respectively), but showed a spike towards the 1980s (0.98 per 100,000 in 1953, 2.4 per 100,000 in 1963, 5.2 per 100,000 in 1973 and 9.1 per 100,000 in 1983). Thereafter, the incidence stabilized (6.0 per 100,000 in 1993 and 7.0 per 100,000 in 2003)29–31.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [29]
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References 22 · Cited by 89
- Authors
- GUNESH, S., THOMAS, G. A. O., WILLIAMS, G. T., ROBERTS, A., & HAWTHORNE, A. B.
- Affiliations
- University Hospital of Wales (GB)
- Corresponding author
- HAWTHORNE, A. B.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-11-14
- Volume
- 27
- Issue
- 3
- Pages
- 211-219
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1563767834
- Cited by
- 89
- References
- 22
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 8
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Keywords
- Crohn's disease, incidence trends, Cardiff, colonic diseases, sex ratio, age at diagnosis, pediatric Crohn's disease, long-term incidence
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Colitis, Crohn Disease, Female, Follow-Up Studies, Humans, Ileitis, Male, Middle Aged, Retrospective Studies, Smoking, Wales, Incidence, Confidence Intervals, Age of Onset, Age Distribution, Sex Distribution, Statistics, Nonparametric
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