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Cited by 113Inflammatory Myopathies and DermatomyositisDysphagia Assessment and ManagementMyasthenia Gravis and Thymoma

Review article: the gastrointestinal complications of myositis

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EBERT, E. C.·2010·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2009.04190.x
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Abstract

BACKGROUND: The inflammatory myopathies are a group of acquired diseases characterized by a proximal myopathy caused by an inflammatory infiltrate of the skeletal muscle. The three major diseases are dermatomyositis, polymyositis and inclusion body myositis. AIMS: To review the gastrointestinal manifestations of myositis. METHODS: Over 110 articles in the English literature were reviewed. RESULTS: Dysphagia to solids and liquids occurs in patients with myositis. The pharyngo-oesophageal muscle tone is lost and therefore patients develop nasal speech, hoarseness, nasal regurgitation and aspiration pneumonia. There is tongue weakness, flaccid vocal cords, poor palatal motion and pooling of secretions in the distended hypopharynx. Proximal oesophageal skeletal muscle dysfunction is demonstrated by manometry with low amplitude/absent pharyngeal contractions and decreased upper oesophageal sphincter pressures. Patients exhibit markedly elevated creatine kinase and lactate dehydrogenase levels consistent with muscle injury. Myositis can be associated with inflammatory bowel disease, coeliac disease and interferon treatment of hepatitis C. Corticosteroids and other immunosuppressive drugs comprise the mainstay of treatment. Inclusion body myositis responds poorly to these agents and therefore a myotomy is usually indicated. CONCLUSION: Myositis mainly involves the skeletal muscles in the upper oesophagus with dysphagia, along with proximal muscle weakness.

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Authors
EBERT, E. C.
Corresponding author
EBERT, E. C.
ORCID
EBERT, E. C.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2010-01-03
Volume
31
Issue
3
Pages
359-365
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2009.04190.x
OpenAlex
W1979823863
Cited by
113
References
0
Citations by year
2026: 2 · 2025: 5 · 2024: 26 · 2023: 4 · 2022: 5 · 2021: 12 · 2020: 6 · 2019: 11 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 8
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
Keywords
myositis, gastrointestinal complications, dysphagia, esophageal dysfunction, aspiration pneumonia, inclusion body myositis, polymyositis, dermatomyositis, inflammatory bowel disease, celiac disease, interferon therapy, manometry, creatine kinase, corticosteroids, immunosuppressive therapy, myotomy
MeSH terms
Gastrointestinal Diseases, Humans, Myositis, Practice Patterns, Physicians', Prognosis, Muscle, Skeletal, Muscle Weakness

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