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Tramadol: pain relief by an opioid without depression of respiration
Abstract
Summary: Two independent clinical trials were conducted simultaneously. In one, tramadol and pethidine were compared in 30 patients by patient‐controlled analgesia during the first 24 h following abdominal surgery. The mean 24 h consumption of tramadol and pethidine was 642 mg and 606 mg respectively, giving a potency estimate of tramadol relative to pethidine of 0.94 (95% confidence interval 0.72–1.17). In the second trial, the effect on respiration of three doses of tramadol (0.5, 1.0, and 2.0 mg.kg −1 ) was compared with that of morphine sulphate (0.143 mg.kg −1 ) by intravenous injection during stable halothane anaesthesia. At approximately 1.5 times the equipotent dose, as estimated from the first trial, tramadol transiently depressed the rate of respiration but had no effect on end‐tidal carbon dioxide tension. Morphine caused apnoea or considerable depression of ventilation. The results suggest that mechanisms other than opioid receptor activity play a significant role in the analgesia produced by tramadol.
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The hypoalgesic effect of tramadol in relation to CYP2D6*
Poulsen, L., Arendt-Nielsen, L., Brøsen, K., & Sindrup, S. H. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90211-8 · Cited by 386
Update on Bispectral Index monitoring
Johansen, J. W. (2006) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 313
The efficacy of combination analgesic therapy in relieving dental pain
MEHLISCH, D. R. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0300 · Cited by 141
Metadata
- Authors
- VICKERS, M. D., O'FLAHERTY, D., SZEKELY, S. M., READ, M., & YOSHIZUMI, J.
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 1992-04
- Volume
- 47
- Issue
- 4
- Pages
- 291-296
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W2013317282
- Cited by
- 423
- References
- 0
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tramadol: pain relief by an opioid without depression of respiration. https://app.cochat.ai/papers/10.1111/j.1365-2044.1992.tb02166.x
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- VICKERS, M. D., O'FLAHERTY, D., SZEKELY, S. M., READ, M., & YOSHIZUMI, J. (1992). Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia. https://doi.org/10.1111/j.1365-2044.1992.tb02166.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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