The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The mechanisms of carbon monoxide production by inhalational agents
Open accessAbstract
Summary: Carbon monoxide can be formed when volatile anaesthetic agents such as desflurane and sevoflurane are used with anaesthetic breathing systems containing carbon dioxide absorbents. This review describes the possible chemical processes involved and summarises the experimental and clinical evidence for the generation of carbon monoxide. We emphasise the different conditions that were used in the experimental work, and explain some of the features of the clinical reports. Finally, we provide guidelines for the prevention and detection of this complication.
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In the citing paper
“In general, anesthesia systems and their components can be safely used with FGFs ≤ 1 L·min-1 under the following conditions: 1) little systemic leakage; 2) mandatory measurement of inspiratory and expiratory concentration of oxygen, carbon dioxide, and inhalational anesthetics; and 3) presence of an integrated carbon dioxide absorber.”
From A call for immediate climate action in anesthesiology: routine use of minimal or metabolic fresh gas flow reduces our ecological footprint (2023) · cites this paper as [50]
Citations
Cites
Reaction of Sevoflurane and Its Degradation Products with Soda Lime
Morio, M., Fujii, K., Satoh, N., Imai, M., Kawakami, U., Mizuno, T., Kawai, Y., Ogasawara, Y., Tamura, T., Negishi, A., et al. (1992) · Anesthesiology · doi:10.1097/00000542-199212000-00017 · Cited by 231
Fang, Z., Eger, E. I., Laster, M. J., Chortkoff, B. S., Kandel, L. B., & Ionescu, P. (1995) · Anesthesia & Analgesia · doi:10.1097/00000539-199506000-00021 · Cited by 177
Murray, J. M., Renfrew, C. W., Bedi, A., McCrystal, C. B., Jones, D. S., & Fee, H. J. P. (1999) · Anesthesiology · doi:10.1097/00000542-199911000-00026 · Cited by 111
Stability of Sevoflurane in Soda Lime
Strum, D. P., Johnson, B. H., & Eger, E. I. (1987) · Anesthesiology · doi:10.1097/00000542-198711000-00024 · Cited by 76
Kharasch, E. D., Powers, K. M., & Artru, A. A. (2002) · Anesthesiology · doi:10.1097/00000542-200201000-00031 · Cited by 71
Mechanistic Aspects of Carbon Monoxide Formation from Volatile Anesthetics
Baxter, P. J., Garton, K. J., & Kharasch, E. D. (1998) · Anesthesiology · doi:10.1097/00000542-199810000-00018 · Cited by 68
Severe Carbon Monoxide Poisoning during Desflurane Anesthesia
Berry, P. D., Sessler, D. I., & Larson, M. D. (1999) · Anesthesiology · doi:10.1097/00000542-199902000-00036 · Cited by 65
Frink, E. J., Nogami, W. M., Morgan, S. E., & Salmon, R. C. (1997) · Anesthesiology · doi:10.1097/00000542-199708000-00018 · Cited by 63
Neumann, M. A., Laster, M. J., Weiskopf, R. B., Gong, D. H., Dudziak, R., Forster, H., & Eger, E. I. (1999) · Anesthesia & Analgesia · doi:10.1097/00000539-199909000-00046 · Cited by 63
Absorption and Degradation of Sevoflurane and Isoflurane in a Conventional Anesthetic Circuit
Liu, J., Laster, M. J., Eger, E. I., & Taheri, S. (1991) · Anesthesia & Analgesia · doi:10.1213/00000539-199106000-00012 · Cited by 56
Research works printed but not linked: 2
- Baum J, 1998, Die Reaction von Sevofluran mit trockenem Atemkalk –Überlegungen anlässlich eines aktuellen Zwischenfalls, Anästhesiologie and Intensivmedizin, 39, 11
- Anonymous., 1998, Carbon monoxide exposures during inhalation anesthesia: the interaction between halogenated anesthetic agents and carbon dioxide absorbents, Health Devices, 27, 402
Cited by
Inhalational anesthesia vs total intravenous anesthesia (TIVA) for pediatric anesthesia
Lerman, J., & Jöhr, M. (2009) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2009.02962.x · Cited by 101
Chenoweth, J., Albertson, T. E., & Greer, M. R. (2021) · Critical Care Clinics · doi:10.1016/j.ccc.2021.03.010 · Cited by 100
Desflurane: A clinical update of a third‐generation inhaled anaesthetic
Jakobsson, J. (2011) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2011.02600.x · Cited by 75
Shamir, M. Y., Avramovich, A., & Smaka, T. J. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318233041a · Cited by 55
Rübsam, M.-L., Kruse, P., Dietzler, Y., Kropf, M., Bette, B., Zarbock, A., Kim, S.-C., & Hönemann, C. (2023) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/s12630-022-02393-z · Cited by 39
“It is important to prevent accidental dry-out of the carbon dioxide absorber and to use it according to the manufacturers’ instructions and recommendations.(50)”
Method
Metadata
- Authors
- Coppens, M. J., Versichelen, L. F. M., Rolly, G., Mortier, E. P., & Struys, M. M. R. F.
- Affiliations
- Ghent University Hospital (BE)
- Corresponding author
- Coppens, M. J.
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 2006-03-28
- Volume
- 61
- Issue
- 5
- Pages
- 462-468
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W2032826125
- Cited by
- 38
- References
- 31
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2 · 2012: 4
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Keywords
- carbon monoxide production, inhalational anesthetics, desflurane, sevoflurane, CO2 absorbents, anaesthetic breathing systems, anesthesia complications
- MeSH terms
- Absorption, Sevoflurane, Desflurane, Adolescent, Anesthesia, Closed-Circuit, Animals, Carbon Monoxide, Child, Preschool, Female, Humans, Isoflurane, Male, Methyl Ethers, Middle Aged, Oxides, Sodium Hydroxide, Swine, Gas Scavengers, Calcium Compounds, Anesthetics, Inhalation
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- CoChat. (2026). Citation check: The mechanisms of carbon monoxide production by inhalational agents. https://app.cochat.ai/papers/10.1111/j.1365-2044.2006.04536.x
- The paper
- Coppens, M. J., Versichelen, L. F. M., Rolly, G., Mortier, E. P., & Struys, M. M. R. F. (2006). The mechanisms of carbon monoxide production by inhalational agents. Anaesthesia. https://doi.org/10.1111/j.1365-2044.2006.04536.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
