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Cited by 53Circadian rhythm and melatoninNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission.

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Cowen, PJ, Green, AR, Grahame‐Smith, DG, Braddock, LE·1985·British Journal of Clinical Pharmacology
DOI 10.1111/j.1365-2125.1985.tb02717.xPMC PMC1463888
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Abstract

Plasma melatonin was used to determine overall beta‐adrenergic transmission through pineal neuro‐effector junctions during desmethylimipramine (DMI) treatment in 10 normal subjects. Changes in plasma melatonin indicated that an initial increase in noradrenaline (NA) transmission produced by DMI was counteracted by adaptive changes which restored transmission to normal by the third week of treatment. A 'rebound' increase in NA transmission was seen on DMI withdrawal. The results suggest that the adaptive changes which occur in NA synapses during DMI treatment do not, as has been proposed, decrease NA transmission below normal levels, but instead restore homeostasis in the presence of the drug.

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Crossref · 10.1111/j.1365-2125.1985.tb02717.x

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Authors
Cowen, P., Green, A., Grahame‐Smith, D., & Braddock, L.
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
1985-06
Volume
19
Issue
6
Pages
799-805
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1111/j.1365-2125.1985.tb02717.x
PMC
PMC1463888
OpenAlex
W1963836596
Cited by
53
References
0
Citations by year
2023: 1 · 2017: 2 · 2013: 1 · 2012: 1
FWCI
3.94
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9917 d)
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
plasma melatonin, desmethylimipramine, pineal gland, drug withdrawal, rebound, homeostasis, tricyclic antidepressants
MeSH terms
Adult, Desipramine, Humans, Male, Melatonin, Synaptic Transmission, Norepinephrine

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