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Amphetamine‐like effects in humans of the khat alkaloid cathinone.
Open accessAbstract
1. The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be due to the phenylalkylamine alkaloid cathinone. In order to determine the effects of this substance in humans, a single oral dose of cathinone or placebo was administered to six healthy male volunteers in a double‐ blind, random order crossover study. 2. Cathinone produced increases in blood pressure and in heart rate, and these changes were concomitant with the presence of cathinone in blood plasma. 3. The physical and mental changes that the subjects reported during the experiment indicated that cathinone has in humans euphorigenic and psychostimulant effects. 4. These observations support the assumption that cathinone is the constituent mainly responsible for the effects of khat, and they show that this alkaloid has also in humans amphetamine‐like effects.
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Citations
Cited by
Rosenbaum, C. D., Carreiro, S. P., & Babu, K. M. (2012) · Journal of Medical Toxicology · doi:10.1007/s13181-011-0202-2 · Cited by 355
Khat: pharmacological and medical aspects and its social use in Yemen
Al‐Motarreb, A., Baker, K., & Broadley, K. J. (2002) · Phytotherapy Research · doi:10.1002/ptr.1106 · Cited by 351
Khat and synthetic cathinones: a review
Valente, M. J., Guedes de Pinho, P., de Lourdes Bastos, M., Carvalho, F., & Carvalho, M. (2014) · Archives of Toxicology · doi:10.1007/s00204-013-1163-9 · Cited by 337
Habitual Khat and Concurrent Khat and Tobacco Use Are Associated With Subjective Sleep Quality
Nakajima, M., Dokam, A., Kasim, A. N., Alsoofi, M., Khalil, N. S., & al’Absi, M. (2014) · Preventing Chronic Disease · doi:10.5888/pcd11.130234 · Cited by 26
Metadata
- Authors
- Brenneisen, R., Fisch, H., Koelbing, U., Geisshusler, S., & Kalix, P.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1990-12
- Volume
- 30
- Issue
- 6
- Pages
- 825-828
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2078502648
- Cited by
- 261
- References
- 0
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brenneisen, R., Fisch, H., Koelbing, U., Geisshusler, S., & Kalix, P. (1990). Amphetamine‐like effects in humans of the khat alkaloid cathinone. British Journal of Clinical Pharmacology. https://doi.org/10.1111/j.1365-2125.1990.tb05447.x
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