The DOI matches its Crossref record.
Effect of L-dopa on the seborrhoea of Parkinsonism
Abstract
By studying the sebum excretion rate in patients with Parkinsonism before and during treatment with L‐dopa we have shown that L‐dopa reduces sebum excretion if seborrhoea is initially present, but has no effect on normal sebum excretion rates. The seborrhoea of Parkinsonism may be due to increased production of melanocyte‐stimulating hormone, and our finding may have therapeutic implications in Parkinsonism and breast cancer.
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α-melanocyte stimulating hormone (α-MSH) levels were elevated in Parkinson patients, possibly due to inadequate dopaminergic input.
“Consistent with this notion, α-melanocyte stimulating hormone (α-MSH) levels were elevated in Parkinson patients, possibly due to inadequate dopaminergic input.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [92]
Treatment with L-dopa reduced α-MSH and re-established the synthesis of MSH-inhibiting factor, reducing sebum secretion.
“Moreover, treatment with L-dopa reduced α-MSH, and re-established the synthesis of MSH-inhibiting factor, reducing sebum secretion [26,92].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [92]
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Research works printed but not linked: 18
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Cited by
Sorted by citations
Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
Metadata
- Authors
- BURTON, J. L., CARTLIDGE, M., & SHUSTER, S.
- Affiliations
- Newcastle University (GB)
- ORCID
- SHUSTER, SAM
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-05
- Volume
- 88
- Issue
- 5
- Pages
- 475-479
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2009923372
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- L-DOPA, parkinsonism, seborrhea, sebum excretion rate, melanocyte-stimulating hormone, breast cancer
- MeSH terms
- Adult, Aged, Depression, Chemical, Dihydroxyphenylalanine, Female, Humans, Male, Middle Aged, Parkinson Disease, Sebaceous Glands, Dermatitis, Seborrheic, Sebum, Secretory Rate
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