The DOI matches its Crossref record.
A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa
Abstract
In order to examine whether anti-androgen therapy was effective in hidradenitis suppurativa (HS), ethinyloestradiol 50 micrograms/cyproterone acetate 50 mg in a reverse sequential regimen was compared with ethinyloestradiol 50 micrograms/norgestrel 500 micrograms (Eugynon 50) in 24 female patients. Both treatments produced substantial improvement in disease activity. Seven patients cleared and have remained free of disease for 18 months, five patients improved, four remained unchanged, while two deteriorated. Cyproterone acetate was not clinically significantly more effective than E50, and both gave a similar reduction in free androgen index. Anti-androgen therapy appears to be beneficial in the treatment of hidradenitis suppurativa.
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Citations
Cited by
Jemec, G. B. E. (2012) · New England Journal of Medicine · doi:10.1056/nejmcp1014163 · Cited by 817
Kimball, A. B., Kerdel, F., Adams, D., Mrowietz, U., Gelfand, J. M., Gniadecki, R., Prens, E. P., Schlessinger, J., Zouboulis, C. C., van der Zee, H. H., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-12-201212180-00004 · Cited by 428
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369
Revuz, J. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03356.x · Cited by 336
Hidradenitis suppurativa: pathogenesis and management
Slade, D. E. M., Powell, B. W., & Mortimer, P. S. (2003) · British Journal of Plastic Surgery · doi:10.1016/s0007-1226(03)00177-2 · Cited by 290
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Metadata
- Authors
- MORTIMER, P. S., DAWBER, R. P. R., GALES, M. A., & MOORE, R. A.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-09
- Volume
- 115
- Issue
- 3
- Pages
- 263-268
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2032710959
- Cited by
- 259
- References
- 0
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa. https://app.cochat.ai/papers/10.1111/j.1365-2133.1986.tb05740.x
- The paper
- MORTIMER, P. S., DAWBER, R. P. R., GALES, M. A., & MOORE, R. A. (1986). A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.1986.tb05740.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
