The DOI matches its Crossref record.
The permissive effect of sebum in seborrhoeic dermatitis: an explanation of the rash in neurological disorders
Abstract
The hypothesis that sebum permits the growth of Pityrosporum ovale, and hence the development of seborrhoeic dermatitis, was tested by observing whether a reduction of sebum production by isotretinoin would improve the disorder. In 10 male patients with seborrhoeic dermatitis, treatment with isotretinoin for 6 weeks reduced the mean sebum excretion rate by 70% and improved the severity of the rash, but with a site difference in magnitude of response. It is concluded that the residual pool of sebum is important for the growth of P. ovale and that, within the physiological range, sebum has a permissive effect on the growth of this yeast. Variation in the pools of residual sebum explains a number of features of the disease such as site of involvement and greater prevalence in males than females. The pathological increase in the residual pool of sebum due to immobility explains the frequent occurrence of seborrhoeic dermatitis in patients with a variety of neurological disorders.
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Sustained reservoirs of residual sebum associated with immobility may influence the manifestation of the disease.
“Because poor hygiene has been implicated in SD, these observations suggest that sustained reservoirs of residual sebum associated with immobility may influence the manifestation of the disease [3,22,26,88].”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [88]
The high incidence of SD in patients with Parkinson's disease and neuroleptic-induced Parkinsonism has long been observed, especially in those with severe seborrhea.
“The high incidence of SD in patients with Parkinson’s disease [17,87,88] and neuroleptic-induced Parkinsonism [89,90] has long been observed, especially in those with severe seborrhea, which provides favorable conditions for Malassezia proliferation.”
From Seborrheic Dermatitis and Dandruff: A Comprehensive Review (2015) · cites this paper as [88]
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Research works printed but not linked: 19
- Shuster S, 1984, Br J Dermatol, 111, 235, 10.1111/j.1365-2133.1984.tb04050.x · DOI · Paper page
- Ford GP, 1984, Br J Dermatol, 603, 10.1111/j.1365-2133.1984.tb06631.x · DOI
- Skinner RB, 1985, J Am Acad Dermatol, 12, 852, 10.1016/S0190-9622(85)70107-7 · DOI
- Roberts SOB, 1969, Br J Dermatol, 81, 264, 10.1111/j.1365-2133.1969.tb13978.x · DOI
- Kligman AM, 1983, Seminars in Dermatology, 2, 57
- Burton JL, 1983, Br Med J, 286, 1169, 10.1136/bmj.286.6372.1169 · DOI · Paper page
- Lookingbill DP, 1986, Br J Dermatol, 114, 75, 10.1111/j.1365-2133.1986.tb02781.x · DOI
- Jones DH, 1983, Br J Dermatol, 108, 333, 10.1111/j.1365-2133.1983.tb03973.x · DOI
- Marsden JR, 1984, Retinoid Therapy-a Review of Clinical and Laboratory Research, 267, 10.1007/978-94-011-6349-1_28 · DOI
- Burton JL, 1986, Textbook oj Dermatology, 375
- Krestin D, 1927, Quarterly J Med, 21, 177, 10.1093/qjmed/os-21.81.177 · DOI
- Bettley FR, 1956, Arch Dermatol, 73, 110, 10.1001/archderm.1956.01550020010002 · DOI · Paper page
- Wilson CL, 1988, Br J Dermatol, 119, 48s, 10.1111/j.1365-2133.1988.tb05386.x · DOI
- Pochi PE, 1962, J Invest Dermatol, 38, 45, 10.1038/jid.1962.10 · DOI
- Burton JL, 1973, Br. J Dermatol, 88, 263, 10.1111/j.1365-2133.1973.tb07545.x · DOI · Paper page
- 10.1111/1523-1747.ep12676782 · DOI
- Thody AJ, 1989, Phys Rev, 69, 383
- Cunliffe WJ, 1969, Br J Dermatol, 81, 697, 10.1111/j.1365-2133.1969.tb16211.x · DOI
- Burton JL, 1971, Br J Dermatol, 84, 135, 10.1111/j.1365-2133.1971.tb06856.x · DOI
Cited by
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Seborrheic Dermatitis and Dandruff: A Comprehensive Review
(2015) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000019 · Cited by 398
Metadata
- Authors
- COWLEY, N. C., FARR, P. M., & SHUSTER, S.
- Affiliations
- Royal Victoria Infirmary (GB)
- Corresponding author
- FARR, P.M.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01
- Volume
- 122
- Issue
- 1
- Pages
- 71-76
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2077371934
- Cited by
- 64
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Keywords
- seborrheic dermatitis, sebum, Pityrosporum ovale, isotretinoin, sebum excretion rate, permissive effect, neurological disorders, immobility, sex differences
- MeSH terms
- Adult, Humans, Male, Middle Aged, Nervous System Diseases, Dermatitis, Seborrheic, Sebum, Secretory Rate, Isotretinoin
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