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The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis
Abstract
A double-blind, randomized, cross-over study was carried out on the effect of a sedative and a non-sedative antihistamine on 25 adults with atopic dermatitis. Intensity of itch was recorded using a computerized method for self-assessment (Pain-Track) and using conventional visual analogue scales. The antipruritic effect of 3 days of treatment with the non-sedative H1 antagonist terfenadine (60 mg b.i.d.) and with the sedative antihistamine, clemastine (2 mg b.i.d.) did not differ from that found with the placebo. Our findings support the view that histamine is not of importance in the pathogenesis of itch in atopic dermatitis.
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Cited by
Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14891 · Cited by 1,181
Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14888 · Cited by 684
Akdis, C. A., Akdis, M., Bieber, T., Bindslev-Jensen, C., Boguniewicz, M., Eigenmann, P., Hamid, Q., Kapp, A., Leung, D. Y. M., Lipozencic, J., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.045 · Cited by 460
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice
Kuraishi, Y., Nagasawa, T., Hayashi, K., & Satoh, M. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00780-b · Cited by 398
Greaves, M. W. (2005) · Skin Pharmacology and Physiology · doi:10.1159/000086667 · Cited by 63
Metadata
- Authors
- WAHLGREN, C.-F., HAGERMARK, O., & BERGSTROM, R.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-04
- Volume
- 122
- Issue
- 4
- Pages
- 545-551
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W1996903618
- Cited by
- 162
- References
- 0
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. https://app.cochat.ai/papers/10.1111/j.1365-2133.1990.tb14732.x
- The paper
- WAHLGREN, C.-F., HAGERMARK, O., & BERGSTROM, R. (1990). The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.1990.tb14732.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
