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Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis
Abstract
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis. Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN.
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Citations
Cited by
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(2010) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2010.08.002 · Cited by 957
Lonjou, C., Borot, N., Sekula, P., Ledger, N., Thomas, L., Halevy, S., Naldi, L., Bouwes-Bavinck, J.-N., Sidoroff, A., de Toma, C., et al. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f3ef9c · Cited by 624
Self-citationRandomised comparison of thalidomide versus placebo in toxic epidermal necrolysis
Wolkenstein, P., Latarjet, J., Roujeau, J.-C., Duguet, C., Boudeau, S., Vaillant, L., Maignan, M., Schuhmacher, M.-H., Milpied, B., Pilorget, A., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02197-7 · Cited by 428
Self-citationRzany, B., Correia, O., Kelly, J. P., Naldi, L., Auquier, A., & Stern, R. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05418-x · Cited by 348
Schwartz, R. A., McDonough, P. H., & Lee, B. W. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.05.003 · Cited by 316
Metadata
- Authors
- PAUL, C., WOLKENSTEIN, P., ADLE, H., WECHSLER, J., GARCHON, H. J., REVUZ, J., & ROUJEAU, J. C.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-04
- Volume
- 134
- Issue
- 4
- Pages
- 710-714
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2000386027
- Cited by
- 304
- References
- 0
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. https://app.cochat.ai/papers/10.1111/j.1365-2133.1996.tb06976.x
- The paper
- PAUL, C., WOLKENSTEIN, P., ADLE, H., WECHSLER, J., GARCHON, H. J., REVUZ, J., & ROUJEAU, J. C. (1996). Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.1996.tb06976.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
