The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Megakaryocyte development and platelet production
Abstract
Summary: Megakaryocytopoiesis involves the commitment of haematopoietic stem cells, and the proliferation, maturation and terminal differentiation of the megakaryocytic progenitors. Circulating levels of thrombopoietin (TPO), the primary growth‐factor for the megakaryocyte (MK) lineage, induce concentration–dependent proliferation and maturation of MK progenitors by binding to the c‐Mpl receptor and signalling induction. Decreased platelet turnover rates results in increased concentration of free TPO, enabling the compensatory response of marrow MKs to increased platelet production. C‐Mpl activity is orchestrated by a complex cascade of signalling molecules that induces the action of specific transcription factors to drive MK proliferation and maturation. Mature MKs form proplatelet projections that are fragmented into circulating particles. Newly developed thrombopoietic agents operating via c‐Mpl receptor may prove useful in supporting platelet production in thrombocytopenic state. Herein, we review the regulation of megakaryocytopoiesis and platelet production in normal and disease state, and the new approaches to thrombopoietic therapy.
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Cites
Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., & Orkin, S. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80318-9 · Cited by 712
Thrombopoietin: the primary regulator of platelet production [see comments]
Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
Nutt, S. L., Metcalf, D., D'Amico, A., Polli, M., & Wu, L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041535 · Cited by 325
Carpinelli, M. R., Hilton, D. J., Metcalf, D., Antonchuk, J. L., Hyland, C. D., Mifsud, S. L., Di Rago, L., Hilton, A. A., Willson, T. A., Roberts, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401496101 · Cited by 179
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PU.1 and pRB Interact and Cooperate To Repress GATA-1 and Block Erythroid Differentiation
Rekhtman, N., Choe, K. S., Matushansky, I., Murray, S., Stopka, T., & Skoultchi, A. I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7460-7474.2003 · Cited by 102
Cited by
Zhao, M., Perry, J. M., Marshall, H., Venkatraman, A., Qian, P., He, X. C., Ahamed, J., & Li, L. (2014) · Nature Medicine · doi:10.1038/nm.3706 · Cited by 607
Forms of extracellular mitochondria and their impact in health
Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138
Metadata
- Authors
- Deutsch, V. R., & Tomer, A.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2006-07-31
- Volume
- 134
- Issue
- 5
- Pages
- 453-466
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2106117938
- Cited by
- 311
- References
- 6
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- closed
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